Document Detail

Soy-protein consumption and kidney-related biomarkers among type 2 diabetics: a crossover, randomized clinical trial.
MedLine Citation:
PMID:  19758824     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Renal disease is a major problem among diabetic patients. The type of protein consumed may affect alterations in kidney-related biomarkers in these patients. This study sought to assess the effects of soy-protein consumption on renal-related markers among type 2 diabetic patients with nephropathy. METHODS: A crossover, randomized clinical trial was conducted among 14 patients (10 men and 4 women). One diet contained 0.8 g/kg protein (70% animal and 30% vegetable proteins), and a similar diet contained the same amount of protein with 35% animal protein, 35% soy protein, and 30% other vegetable proteins. These two diets were prescribed in each phase of the trial for 7 weeks. There was a 4-week washout between the two phases of the study. RESULTS: Consumption of soy protein reduced urinary urea nitrogen (-0.9 +/- 0.8 vs. 0.2 +/- 0.6 mg/dL, respectively, SD; P < .001), proteinuria (-78 +/- 37 vs. 42 +/- 39 mg/day, respectively, SD; P < .001), blood sodium (-2 +/- 0.04 vs. 2.0 +/- 0.06 mg/dL, respectively, SD; P < .01), and serum phosphorus (-0.03 +/- 0.2 vs. 0.2 +/- 0.3 mg/dL, respectively, SD; P < .01) compared with animal protein. Serum and urinary creatinine, blood urea nitrogen, serum calcium, and potassium levels were not significantly changed in soy-protein versus anima-protein consumption. CONCLUSION: Soy-protein consumption reduces proteinuria in type 2 diabetes with nephropathy.
Leila Azadbakht; Ahmad Esmaillzadeh
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2009-09-15
Journal Detail:
Title:  Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation     Volume:  19     ISSN:  1532-8503     ISO Abbreviation:  J Ren Nutr     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2009-10-12     Completed Date:  2010-01-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9112938     Medline TA:  J Ren Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  479-86     Citation Subset:  IM    
Department of Nutrition, School of Public Health, and Food Security and Nutrition Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
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MeSH Terms
Biological Markers / metabolism
Cross-Over Studies
Diabetes Mellitus, Type 2 / complications,  metabolism*
Diabetic Nephropathies / metabolism*
Diet / methods
Dietary Proteins / administration & dosage,  metabolism
Kidney / metabolism*
Middle Aged
Phosphorus / blood
Proteinuria / etiology,  prevention & control*
Sodium / blood
Soybean Proteins / administration & dosage*,  metabolism*
Urea / urine
Reg. No./Substance:
0/Biological Markers; 0/Dietary Proteins; 0/Soybean Proteins; 57-13-6/Urea; 7440-23-5/Sodium; 7723-14-0/Phosphorus

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