| Soy isoflavones' osteoprotective role in postmenopausal women: mechanism of action. | |
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MedLine Citation:
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PMID: 11893477 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Ovarian hormone deficiency is a major risk factor for osteoporosis. Current therapies emphasize the use of antiresorptive agents, such as estrogen, calcitonin, and bisphosphonates. These therapies are associated with certain risks and side effects making compliance a major obstacle. Recent findings suggest that a class of synthetic and naturally occurring compounds, selective estrogen receptor modulators, e.g. raloxifene and soy isoflavones can offer attractive alternatives. Evidence for bone-sparing effects of isoflavones relies mainly on animal findings supported by a limited number of human studies. These observations suggest that isoflavones exert their effects on bone by stimulating bone formation and at the same time suppressing bone resorption. However, the precise osteoprotective mechanism of isoflavones remains uncertain and awaiting further clarification. From a clinical point of view, larger and longer duration studies are warranted to enable us to draw clear conclusions in regards to the role of isoflavones on bone. |
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Authors:
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Bahram H. Arjmandi; Brenda J. Smith |
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Publication Detail:
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Type: JOURNAL ARTICLE |
Journal Detail:
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Title: The Journal of nutritional biochemistry Volume: 13 ISSN: 1873-4847 ISO Abbreviation: J. Nutr. Biochem. Publication Date: 2002 Mar |
Date Detail:
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Created Date: 2002-Mar-14 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9010081 Medline TA: J Nutr Biochem Country: - |
Other Details:
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Languages: ENG Pagination: 130-137 Citation Subset: - |
Affiliation:
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Department of Nutritional Sciences, 425 Human Environmental Sciences, Oklahoma State University, 74078-6141, Stillwater, OK, USA |
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