Document Detail

Soy isoflavones, Mediterranean diet, and physical exercise in postmenopausal women with insulin resistance.
MedLine Citation:
PMID:  20216276     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The aim of this study was to evaluate whether a standard dose of 40 mg of soy isoflavones prescribed in routine clinical practice for treatment of menopausal symptoms has some influence on glucose homeostasis in postmenopausal women with insulin resistance (IR). METHODS: A total of 116 postmenopausal women with IR were randomly assigned to a group of Mediterranean diet and physical exercise (control group) or a group of Mediterranean diet, physical exercise, and daily oral ingestion of 40 mg of soy isoflavones (soy isoflavones group). Anthropometric measures, Kupperman Index values, Cervantes Scale score, and blood samples for glucose, insulin, lipid profile, creatinine, uric acid, homocysteine, folic acid, vitamin B12, selenium, and estradiol were determined at baseline and at intervals of 6, 12, 18, and 24 months. RESULTS: Mean homeostasis model assessment of IR (HOMA-IR) values remained unchanged from the baseline in the control group but steadily decreased in the soy isoflavones group at 6 months (P = 0.042). There were no statistically significant differences between both groups in mean HOMA-IR scores at baseline, but statistically significantly lower values were found in the soy isoflavones group at 6 months (P = 0.009), 12 months (P = 0.011), 18 months (P = 0.018), and 24 months (P = 0.012). Changes in HOMA-IR values were also clearly related to body mass index (P < 0.001), abdominal circumference (P < 0.001), and treatment (P = 0.044) when a linear regression analysis was carried out. CONCLUSIONS: Daily intake of 40 mg of soy isoflavones together with a Mediterranean diet and exercise reduced IR in postmenopausal women who had IR in the first place. It was significantly better than lifestyle changes alone. If corroborated, this may be a useful intervention for these women.
Placido Llaneza; Celestino Gonzalez; Jose Fernandez-I?arrea; Ana Alonso; Maria J Diaz-Fernandez; Ignacio Arnott; Javier Ferrer-Barriendos
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Menopause (New York, N.Y.)     Volume:  17     ISSN:  1530-0374     ISO Abbreviation:  Menopause     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-03-10     Completed Date:  2010-04-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9433353     Medline TA:  Menopause     Country:  United States    
Other Details:
Languages:  eng     Pagination:  372-8     Citation Subset:  IM    
Obstetrics and Gynecology Department, Asturias Central University Hospital, Oviedo, Spain.
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MeSH Terms
Blood Glucose / analysis
Diet, Mediterranean*
Exercise Therapy*
Insulin / blood
Insulin Resistance / physiology*
Isoflavones / administration & dosage*,  blood
Middle Aged
Models, Biological
Postmenopause / blood,  drug effects*
Soybean Proteins / administration & dosage
Treatment Outcome
Reg. No./Substance:
0/Blood Glucose; 0/Isoflavones; 0/Soybean Proteins; 11061-68-0/Insulin

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