|Soy isoflavone phase II metabolism differs between rodents and humans: implications for the effect on breast cancer risk.|
|PMID: 21955647 Owner: NLM Status: MEDLINE|
|BACKGROUND: Human and animal studies have produced conflicting results with regard to the effect of soy isoflavones on breast cancer risk. This may be due to differences in isoflavone metabolism.
OBJECTIVE: The objective of this study was to determine whether soy isoflavone phase II metabolism differs between humans and rodents.
DESIGN: Circulating total and unconjugated isoflavone concentrations were determined by mass spectrometry in plasma samples from 7 separate studies: 1) in Sprague-Dawley rats and in 3 strains of mice fed commercial soy-containing diets; 2) in Sprague-Dawley rats gavaged with genistein; 3) in healthy adults who consumed single servings of soy nuts, soy milk, and tempeh; 4) in healthy adults subchronically given soy milk; 5) in healthy women orally administered 50 mg genistein; 6) in healthy women orally administered 20 mg pure S-(-)equol; and 7) in 6-mo-old infants fed soy infant formula and later, at age 3 y, a soy germ isoflavone supplement.
RESULTS: The proportion of unconjugated genistein in plasma from adults and infants who consumed different soy foods, pure genistein, or an isoflavone supplement was <1% in steady state and <2% at peak concentrations. By contrast, rodents fed soy-containing diets conjugate isoflavones less efficiently. The plasma percentages of unconjugated genistein concentrations in Sprague-Dawley rats and C57BL/6, nude, and transgenic AngptL4B6 mice were 4.0 ± 0.6%, 4.6 ± 0.6%, 11.6 ± 0%, and 30.1 ± 4.3%, respectively, which represent 20, 23, 58, and 150 times that in humans.
CONCLUSION: The markedly higher circulating concentrations of biologically active (unconjugated) genistein in certain strains of mice cast doubt on the value of the use of these rodents for gaining insight into the effects of isoflavones in humans, especially with regard to the effects on breast tissue.
|Kenneth D R Setchell; Nadine M Brown; Xueheng Zhao; Stephanie L Lindley; James E Heubi; Eileen C King; Mark J Messina|
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|Type: Comparative Study; Journal Article; Randomized Controlled Trial Date: 2011-09-28|
|Title: The American journal of clinical nutrition Volume: 94 ISSN: 1938-3207 ISO Abbreviation: Am. J. Clin. Nutr. Publication Date: 2011 Nov|
|Created Date: 2011-10-21 Completed Date: 2012-02-01 Revised Date: 2013-06-27|
Medline Journal Info:
|Nlm Unique ID: 0376027 Medline TA: Am J Clin Nutr Country: United States|
|Languages: eng Pagination: 1284-94 Citation Subset: AIM; IM|
|Division of Pathology and Laboratory Medicine, Cincinnati Children’s Hospital Medical Center, OH 45229, USA. firstname.lastname@example.org|
|APA/MLA Format Download EndNote Download BibTex|
Breast / drug effects*, metabolism
Breast Neoplasms / chemically induced, prevention & control
Disease Models, Animal
Genistein / blood
Isoflavones / administration & dosage, blood*
Mammary Glands, Animal / drug effects*, metabolism
Mammary Neoplasms, Experimental / chemically induced, prevention & control
Mice, Inbred C57BL
Premenopause / blood
|0/Isoflavones; 446-72-0/Genistein; 6287WC5J2L/daidzein|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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