Document Detail


Soy and isoflavone consumption in relation to prostate cancer risk in China.
MedLine Citation:
PMID:  12869409     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This case-control study in China evaluated the effect of soy food consumption and isoflavones (genistein and daidzein) on the risk of prostate cancer. One hundred and thirty-three cases and 265 age- and residential community-matched controls between the ages of 50 and 89 years were interviewed in person between 1989 and 1992. Usual consumption of soy foods and isoflavones was assessed using a food frequency questionnaire developed in China and a nutrient database developed and validated in Asian-American populations. The age- and total calorie-adjusted odds ratio (OR) of prostate cancer risk comparing the highest tertile of tofu intake to the lowest tertile was 0.58 [95% confidence interval (CI), 0.35-0.96]. There were also statistically significant associations comparing the highest quartile of intake of soy foods (OR, 0.51; 95% CI, 0.28-0.95) and genistein (OR, 0.53; 95% CI, 0.29-0.97) with the lowest quartiles. There was also an indication of a reduced risk associated with intake of daidzein (OR, 0.56; 95% CI, 0.31-1.04 for the highest versus lowest quartile). Our results indicate a reduced risk of prostate cancer associated with consumption of soy foods and isoflavones. These findings should be confirmed in longitudinal follow-up studies in populations with varying risk of prostate cancer.
Authors:
Marion M Lee; Scarlett Lin Gomez; Jeffrey S Chang; Mercy Wey; Run-Tian Wang; Ann W Hsing
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology     Volume:  12     ISSN:  1055-9965     ISO Abbreviation:  Cancer Epidemiol. Biomarkers Prev.     Publication Date:  2003 Jul 
Date Detail:
Created Date:  2003-07-18     Completed Date:  2004-03-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9200608     Medline TA:  Cancer Epidemiol Biomarkers Prev     Country:  United States    
Other Details:
Languages:  eng     Pagination:  665-8     Citation Subset:  IM    
Affiliation:
Department of Epidemiology and Biostatistics, University of California at San Francisco, 94143-0560, USA. mmlee@itsa.ucsf.edu
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MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Case-Control Studies
China / epidemiology
Diet
Genistein / administration & dosage*
Humans
Isoflavones / administration & dosage*
Male
Middle Aged
Odds Ratio
Prostatic Neoplasms / epidemiology,  prevention & control*
Questionnaires
Risk Factors
Soy Foods*
Chemical
Reg. No./Substance:
0/Isoflavones; 446-72-0/Genistein; 486-66-8/daidzein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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