| Soy and isoflavone consumption in relation to prostate cancer risk in China. | |
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MedLine Citation:
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PMID: 12869409 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This case-control study in China evaluated the effect of soy food consumption and isoflavones (genistein and daidzein) on the risk of prostate cancer. One hundred and thirty-three cases and 265 age- and residential community-matched controls between the ages of 50 and 89 years were interviewed in person between 1989 and 1992. Usual consumption of soy foods and isoflavones was assessed using a food frequency questionnaire developed in China and a nutrient database developed and validated in Asian-American populations. The age- and total calorie-adjusted odds ratio (OR) of prostate cancer risk comparing the highest tertile of tofu intake to the lowest tertile was 0.58 [95% confidence interval (CI), 0.35-0.96]. There were also statistically significant associations comparing the highest quartile of intake of soy foods (OR, 0.51; 95% CI, 0.28-0.95) and genistein (OR, 0.53; 95% CI, 0.29-0.97) with the lowest quartiles. There was also an indication of a reduced risk associated with intake of daidzein (OR, 0.56; 95% CI, 0.31-1.04 for the highest versus lowest quartile). Our results indicate a reduced risk of prostate cancer associated with consumption of soy foods and isoflavones. These findings should be confirmed in longitudinal follow-up studies in populations with varying risk of prostate cancer. |
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Authors:
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Marion M Lee; Scarlett Lin Gomez; Jeffrey S Chang; Mercy Wey; Run-Tian Wang; Ann W Hsing |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology Volume: 12 ISSN: 1055-9965 ISO Abbreviation: Cancer Epidemiol. Biomarkers Prev. Publication Date: 2003 Jul |
Date Detail:
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Created Date: 2003-07-18 Completed Date: 2004-03-25 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9200608 Medline TA: Cancer Epidemiol Biomarkers Prev Country: United States |
Other Details:
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Languages: eng Pagination: 665-8 Citation Subset: IM |
Affiliation:
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Department of Epidemiology and Biostatistics, University of California at San Francisco, 94143-0560, USA. mmlee@itsa.ucsf.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Case-Control Studies China / epidemiology Diet Genistein / administration & dosage* Humans Isoflavones / administration & dosage* Male Middle Aged Odds Ratio Prostatic Neoplasms / epidemiology, prevention & control* Questionnaires Risk Factors Soy Foods* |
| Chemical | |
Reg. No./Substance:
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0/Isoflavones; 446-72-0/Genistein; 486-66-8/daidzein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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