Document Detail

Soy intake is associated with lower lung cancer risk: results from a meta-analysis of epidemiologic studies.
MedLine Citation:
PMID:  22071712     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Although several in vitro and animal in vivo studies have suggested that soy or soy isoflavones may exert inhibitory effects on lung carcinogenesis, epidemiologic studies have reported inconclusive results on the association between soy intake and lung cancer.
OBJECTIVE: The aim of this meta-analysis was to investigate whether an association exists between soy and lung cancer in epidemiologic studies.
DESIGN: We searched PubMed, EMBASE, and the Cochrane Library from their inception to February 2011 for both case-control and cohort studies that assessed soy consumption and lung cancer risk. Study-specific risk estimates were combined by using fixed-effect or random-effect models.
RESULTS: A total of 11 epidemiologic studies that consisted of 8 case-control and 3 prospective cohort studies were included. A significantly inverse association was shown between soy intake and lung cancer with an overall RR of 0.77 (95% CI: 0.65, 0.92). Findings were slightly different when analyses were restricted to 5 high-quality studies (RR: 0.70; 95% CI: 0.45, 0.99). In a subgroup meta-analysis, a statistically significant protective effect of soy consumption was observed in women (RR: 0.79; 95% CI: 0.67, 0.93), never smokers (RR: 0.62; 95% CI: 0.51, 0.76), and Asian populations (RR: 0.86; 95% CI: 0.74, 0.98).
CONCLUSIONS: Our findings indicate that the consumption of soy food is associated with lower lung cancer risk. Because of different methods used to assess soy consumption across studies, more well-designed cohort studies or intervention studies that use unified measures of soy intake are needed to fully characterize such an association.
Wan-Shui Yang; Puthiery Va; Man-Yu Wong; Huan-Ling Zhang; Yong-Bing Xiang
Publication Detail:
Type:  Journal Article; Meta-Analysis; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2011-11-09
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  94     ISSN:  1938-3207     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-11-22     Completed Date:  2012-02-03     Revised Date:  2013-06-27    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1575-83     Citation Subset:  AIM; IM    
State Key Laboratory of Oncogene and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, China.
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MeSH Terms
Asian Continental Ancestry Group
Linear Models
Lung Neoplasms / ethnology,  prevention & control*
Plant Preparations / therapeutic use*
Risk Factors
Sex Factors
Soy Foods*
Soybeans* / chemistry
Grant Support
Reg. No./Substance:
0/Plant Preparations

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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