Document Detail


Soy foods and urinary isoprostanes: results from a randomized study in premenopausal women.
MedLine Citation:
PMID:  22331037     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In addition to their antiestrogenic effects, soy isoflavones may protect against cancer through alternate biological actions, for example, antioxidant properties. This randomized crossover study explored the relationship between dietary isoflavone intake through common soy foods and oxidative stress quantified by urinary isoprostane levels. Eighty-two women aged 39.2 ± 6.1 years were randomly selected to receive a high soy diet of 2 soy food servings per day and a low soy diet of <3 servings per week for 6 months each, separated by a 1-month washout period. Urine samples were collected at baseline and at the end of each dietary period. Urinary isoprostane levels were measured using enzyme-linked immunosorbent assays (ELISA) and adjusted for creatinine levels. Mixed models using log-transformed values were applied to evaluate the effect of the high soy diet. Unadjusted isoprostane excretion levels were lower during the high rather than the low soy diet, but this effect was not statistically significant (p = 0.81). After adjustment for urinary creatinine, isoprostane excretion was slightly higher during the high soy diet (p = 0.02), an observation that was confirmed in a regression analysis between urinary isoflavones and isoprostanes during the high soy diet. The original association remained significant when restricted to adherent participants, however this effect disappeared after exclusion of three extreme values. In agreement with several previous reports, these findings do not support the hypothesis that soy exerts antioxidant effects, as measured by urinary isoprostane excretions, but additional markers of oxidative stress need to be investigated in future studies.
Authors:
Cherisse Sen; Yukiko Morimoto; Sreang Heak; Robert V Cooney; Adrian A Franke; Gertraud Maskarinec
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural     Date:  2012-02-14
Journal Detail:
Title:  Food & function     Volume:  3     ISSN:  2042-650X     ISO Abbreviation:  Food Funct     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-05-03     Completed Date:  2012-09-04     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  101549033     Medline TA:  Food Funct     Country:  England    
Other Details:
Languages:  eng     Pagination:  517-21     Citation Subset:  IM    
Affiliation:
University of Hawaii Cancer Center, 1236 Lauhala Street, Honolulu, HI 96813, USA.
Data Bank Information
Bank Name/Acc. No.:
ClinicalTrials.gov/NCT00513916
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MeSH Terms
Descriptor/Qualifier:
Adult
Antioxidants / administration & dosage*
Biological Markers / urine
Creatinine / urine
Cross-Over Studies
Enzyme-Linked Immunosorbent Assay
Female
Humans
Isoflavones / metabolism*,  urine
Isoprostanes / urine*
Oxidative Stress*
Patient Compliance
Premenopause
Questionnaires
Soy Foods* / analysis
Time Factors
Grant Support
ID/Acronym/Agency:
P30 CA071789/CA/NCI NIH HHS; P30 CA71789/CA/NCI NIH HHS; R01 CA080843/CA/NCI NIH HHS; R01 CA80843/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Antioxidants; 0/Biological Markers; 0/Isoflavones; 0/Isoprostanes; 60-27-5/Creatinine
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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