Document Detail

Soy food and isoflavone intake and colorectal cancer risk: The Fukuoka Colorectal Cancer Study.
MedLine Citation:
PMID:  20969489     Owner:  NLM     Status:  In-Data-Review    
Abstract Objective. It has been suggested that soy food and isoflavone intake may be protective against the risk of colorectal cancer. However, epidemiologic evidence remains sparse and inconsistent. We addressed this issue in the Fukuoka Colorectal Cancer Study. Material and methods. The study subjects were the 816 incident cases of histologically confirmed colorectal cancer and 815 community controls. Intakes of soy foods and isoflavones were assessed by in-person interview using a computer-assisted dietary method. Logistic regression analysis was applied to estimate odds ratio (OR) and 95% confidence interval (CI) of colorectal cancer with adjustment for dietary intakes of calcium and n-3 polyunsaturated fatty acids as well as for body mass index, physical activity, alcohol use, and other lifestyle factors. Results. Energy-adjusted intakes of soy foods (dry weight) and isoflavones were inversely associated with colorectal cancer risk in men and postmenopausal women, but not in premenopausal women. The multivariate-adjusted OR for the highest versus lowest quintile was 0.65 (95% CI 0.41-1.03, p for trend = 0.03) for soy foods and 0.68 (95% CI 0.42-1.10, p for trend = 0.051) for isoflavones in men. The corresponding values for postmenopausal women were 0.60 (95% CI 0.29-1.25, p for trend = 0.053) and 0.68 (95% CI 0.33-1.40, p for trend = 0.049). The site-specific analysis showed inverse associations of soy foods (p for trend = 0.007) and isoflavones (p for trend = 0.02) with rectal cancer in men. Conclusion. The findings add to epidemiologic evidence for protective effects of soy foods and isoflavones in colorectal carcinogenesis.
Sanjeev Budhathoki; Amit Man Joshi; Keizo Ohnaka; Guang Yin; Kengo Toyomura; Suminori Kono; Ryuichi Mibu; Masao Tanaka; Yoshihiro Kakeji; Yoshihiko Maehara; Takeshi Okamura; Koji Ikejiri; Kitaroh Futami; Takafumi Maekawa; Yohichi Yasunami; Kenji Takenaka; Hitoshi Ichimiya; Reiji Terasaka
Related Documents :
11874749 - Comparing ophthalmoscopy, slide viewing, and semiautomated systems in optic disc morpho...
17444219 - Chromatographic and electrophoretic approaches for the analysis of protein quality of s...
23134669 - Contextual determinants of health behaviours in an aboriginal community in canada: pilo...
9395689 - A comparative survey of leguminous plants as sources of the isoflavones, genistein and ...
17913229 - Selenium.
18974939 - The analysis of copper, selenium, and molybdenum contents in frequently consumed foods ...
15990789 - Advances in allergic skin disease, anaphylaxis, and hypersensitivity reactions to foods...
4091559 - Comparison of enrichment broths for isolation of campylobacter jejuni.
8946709 - Relative effectiveness of selenite cystine broth, tetrathionate broth, and rappaport-va...
Publication Detail:
Type:  Journal Article     Date:  2010-10-24
Journal Detail:
Title:  Scandinavian journal of gastroenterology     Volume:  46     ISSN:  1502-7708     ISO Abbreviation:  Scand. J. Gastroenterol.     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-01-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0060105     Medline TA:  Scand J Gastroenterol     Country:  England    
Other Details:
Languages:  eng     Pagination:  165-72     Citation Subset:  IM    
Department of Preventive Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Optimal number of biopsies to correctly identify colorectal cancer during colonoscopy.
Next Document:  Down-regulation of Bcl-2 is mediated by NF-?B activation in Helicobacter pylori-induced apoptosis of...