| Soy-diet has beneficial effects on cardiovascular parameters that are independent of its lipid effect in male hypercholesterolemic rats. | |
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MedLine Citation:
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PMID: 19107839 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Diet-induced atherosclerosis is lower in animals fed soy protein. The effects of various soy components have been extensively studied; however, little is known about the effect of crude soybean feeding on hypercholesterolemia-induced cardiovascular changes. This study investigated the effect of soy feeding on cardiovascular parameters in hypercholesterolemic male rats. Total cholesterol (TC), low density lipoprotein (LDL) and high density lipoprotein cholesterol (HDL), and triglyceride (TG) were measured. Rats were randomly assigned to control, high cholesterol (HC, 2% cholesterol) or HC + soy (HC+S) diets. In the HC+S group, rats received HC diet for 10 weeks followed by 2 weeks of soybean feeding. Arterial blood pressure, TC, TG, LDL and HDL were measured. TC, TG and LDL were higher in HC rats and were not significantly reduced by soybean feeding. Soy feeding reversed the HC-induced increase in arterial blood pressure and also restored the impaired vascular responses to acetylcholine in isolated aortic rings. Pre-incubation of HC+S aortic rings with L-NAME (10(-5) M for 20 min) partially reduced the effects of soy on acetylcholine responses, indicating that the beneficial vascular effects of dietary soy are partially mediated via nitric oxide pathway. |
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Authors:
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M Fatehi; K Farrokhfall; S Davoudi; T M Collins; Z Fatehi-Hassanabad |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Phytotherapy research : PTR Volume: 23 ISSN: 1099-1573 ISO Abbreviation: Phytother Res Publication Date: 2009 May |
Date Detail:
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Created Date: 2009-04-29 Completed Date: 2009-05-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8904486 Medline TA: Phytother Res Country: England |
Other Details:
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Languages: eng Pagination: 624-7 Citation Subset: IM |
Affiliation:
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Department of Physiology & Pharmacology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. zfatehi@upei.ca |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Aorta / drug effects Blood Pressure* Cardiovascular Agents / pharmacology* Cholesterol, Dietary / adverse effects Cholesterol, HDL / blood Cholesterol, LDL / blood Diet Hypercholesterolemia / diet therapy* Male NG-Nitroarginine Methyl Ester / pharmacology Nitric Oxide / metabolism Random Allocation Rats Rats, Sprague-Dawley Soybeans* Triglycerides / blood |
| Chemical | |
Reg. No./Substance:
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0/Cardiovascular Agents; 0/Cholesterol, Dietary; 0/Cholesterol, HDL; 0/Cholesterol, LDL; 0/Triglycerides; 10102-43-9/Nitric Oxide; 50903-99-6/NG-Nitroarginine Methyl Ester |
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