| Soy-derived isoflavones treatment in children with hypercholesterolemia: a pilot study. | |
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MedLine Citation:
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PMID: 20432816 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIMS: To evaluate for the first time in children the effect of soy-derived isoflavones on lipid profile and insulin resistance. METHODS: Twelve hypercholesterolemic children (8 females) aged 5.3 to 11.2 years have completed a prospective, controlled pilot study. After a low-fat diet for 12 weeks, children who maintained high cholesterol and low-density lipoprotein-cholesterol (LDL-C) levels were randomly assigned to three intervention periods of either placebo or low and high dose isoflavone (16 or 48 mg) consumption, each period lasting 8 weeks. RESULTS: The diet significantly reduced LDL-C and apolipoprotein B (Apo B) levels. However, isoflavones had no effect on cholesterol, LDL-C, high-density lipoprotein-cholesterol (HDL-C), triglycerides, lipoprotein (a), Apo B, or insulin resistance, at either low or high doses. Isoflavones had no effect on sex hormones, gonadotropins, sex-hormone binding globulin and thyroid hormones. CONCLUSIONS: The results of this pilot study do not suggest a beneficial role of an isoflavone-enriched diet in children with hypercholesterolemia. |
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Authors:
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Amnon Zung; Sabina Shachar; Zvi Zadik; Zohar Kerem |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Journal of pediatric endocrinology & metabolism : JPEM Volume: 23 ISSN: 0334-018X ISO Abbreviation: J. Pediatr. Endocrinol. Metab. Publication Date: 2010 Jan-Feb |
Date Detail:
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Created Date: 2010-05-03 Completed Date: 2010-05-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9508900 Medline TA: J Pediatr Endocrinol Metab Country: England |
Other Details:
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Languages: eng Pagination: 133-41 Citation Subset: IM |
Affiliation:
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Pediatric Endocrinology Unit, Kaplan Medical Center, Rehovot, Israel. amzung2@bezeqint.net |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Apolipoproteins B
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blood Child Child, Preschool Cholesterol, HDL / blood Cholesterol, LDL / blood Cross-Over Studies Diet, Fat-Restricted* Dose-Response Relationship, Drug Female Food, Fortified* Gonadal Steroid Hormones / blood Gonadotropins / blood Humans Hypercholesterolemia / blood, diet therapy*, epidemiology Insulin Resistance Isoflavones / administration & dosage* Male Pilot Projects Placebos Prospective Studies Risk Factors Sex Hormone-Binding Globulin / metabolism Soy Foods* Triglycerides / blood |
| Chemical | |
Reg. No./Substance:
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0/Apolipoproteins B; 0/Cholesterol, HDL; 0/Cholesterol, LDL; 0/Gonadal Steroid Hormones; 0/Gonadotropins; 0/Isoflavones; 0/Placebos; 0/Sex Hormone-Binding Globulin; 0/Triglycerides |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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