Document Detail

Soy consumption and histopathologic markers in breast tissue using tissue microarrays.
MedLine Citation:
PMID:  19838945     Owner:  NLM     Status:  MEDLINE    
This study examined the relation of soy intake with hormonal and proliferation markers in benign and malignant breast tissue using tissue microarrays (TMAs). TMAs with up to 4 malignant and 4 benign tissue samples for 268 breast cancer cases were constructed. Soy intake in early life and in adulthood was assessed by questionnaire. The TMAs were stained for estrogen receptor (ER) alpha, ERbeta, progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2/neu), proliferating cell nuclear antigen (PCNA), and Ki-67 using standard immunohistochemical methods. Logistic regression was applied for statistical analysis. A higher percentage of women showed positive marker expression in malignant than in benign tissue. With one exception, HER2/neu, no significant associations between soy intake and pathologic markers were observed. Early life soy intake was associated with lower HER2/neu and PCNA staining of malignant tissue. In benign tissue, early life soy intake showed higher ER and PR expression, but no difference in proliferation markers. The results of this investigation provide some assurance that soy intake does not adversely affect markers of proliferation. TMAs were shown to be a useful tool for epidemiologic research.
Gertraud Maskarinec; Eva Erber; Martijn Verheus; Brenda Y Hernandez; Jeffrey Killeen; Suzanne Cashin; J Mark Cline
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Nutrition and cancer     Volume:  61     ISSN:  1532-7914     ISO Abbreviation:  Nutr Cancer     Publication Date:  2009  
Date Detail:
Created Date:  2009-10-19     Completed Date:  2010-01-15     Revised Date:  2014-09-22    
Medline Journal Info:
Nlm Unique ID:  7905040     Medline TA:  Nutr Cancer     Country:  United States    
Other Details:
Languages:  eng     Pagination:  708-16     Citation Subset:  IM    
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MeSH Terms
Anticarcinogenic Agents / administration & dosage*
Body Mass Index
Breast / chemistry*
Breast Neoplasms / chemistry,  epidemiology,  ethnology,  pathology*
Diet Surveys
Ki-67 Antigen / analysis
Logistic Models
Middle Aged
Proliferating Cell Nuclear Antigen / analysis
Receptor, Epidermal Growth Factor / analysis
Receptors, Estrogen / analysis
Receptors, Progesterone / analysis
Soy Foods* / adverse effects,  statistics & numerical data
Tissue Array Analysis / methods*
Tumor Markers, Biological / analysis*
Grant Support
R01 CA085265/CA/NCI NIH HHS; R01 CA085265-03/CA/NCI NIH HHS; R01 CA85265/CA/NCI NIH HHS; R21 CA1080250/CA/NCI NIH HHS; R21 CA108250/CA/NCI NIH HHS; R21 CA108250-02/CA/NCI NIH HHS; R37 CA 54281/CA/NCI NIH HHS; R37 CA054281/CA/NCI NIH HHS; R37 CA054281-17/CA/NCI NIH HHS
Reg. No./Substance:
0/Anticarcinogenic Agents; 0/Ki-67 Antigen; 0/Proliferating Cell Nuclear Antigen; 0/Receptors, Estrogen; 0/Receptors, Progesterone; 0/Tumor Markers, Biological; EC, Epidermal Growth Factor

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