Document Detail

Soy Saponins Meditate the Progression of Colon Cancer in Rats by Inhibiting the Activity of β -Glucuronidase and the Number of Aberrant Crypt Foci but Not Cyclooxygenase-2 Activity.
MedLine Citation:
PMID:  24224098     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Objective. The effect of extracted crude soybean saponins on preneoplastic lesions, aberrant crypt foci (ACF), and the related mechanism were investigated. Research Methods and Procedures. Rats were assigned into five groups according to different doses of extracted crude soybean saponins and received 1,2-dimethylhydrazine (DMH) injection in week 5. In week 15, all rats were sacrificed. The number of ACFs, the cyclooxygenase-2 (COX-2) protein expression, the level of prostaglandins E2 (PGE2), and the activity of β -glucuronidase were examined. Results. Results revealed that the consumption of extracted crude soybean saponins decreased the number of ACFs and the activity of β -glucuronidase in rats, while the expression of COX-2 protein and PGE2 level were not affected. Conclusions. Soybean saponins were effective in inhibiting colon cancer by downregulating the activity of β -glucuronidase in colonic mucosa but not the COX-2 protein expression and PGE2 level.
Yu-Wei Guo; Yue-Hwa Chen; Wan-Chun Chiu; Hsiang Liao; Shyh-Hsiang Lin
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Publication Detail:
Type:  Journal Article     Date:  2013-10-02
Journal Detail:
Title:  ISRN oncology     Volume:  2013     ISSN:  2090-5661     ISO Abbreviation:  ISRN Oncol     Publication Date:  2013  
Date Detail:
Created Date:  2013-11-13     Completed Date:  2013-11-13     Revised Date:  2014-01-24    
Medline Journal Info:
Nlm Unique ID:  101567026     Medline TA:  ISRN Oncol     Country:  Egypt    
Other Details:
Languages:  eng     Pagination:  645817     Citation Subset:  -    
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