Document Detail


Soy food intake and risk of lung cancer: evidence from the Shanghai Women's Health Study and a meta-analysis.
MedLine Citation:
PMID:  23097255     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The authors prospectively evaluated the association of soy food intake with lung cancer risk, overall and by tumor aggressiveness, and performed a meta-analysis of published data. Included in the analysis were 71,550 women recruited into the Shanghai Women's Health Study (Shanghai, China) in 1997-2000. Usual soy food intake was assessed at baseline and reassessed during follow-up through in-person interviews. During a mean follow-up period of 9.1 years, 370 incident lung cancer cases were identified; 340 patients were lifetime never smokers. After adjustment for potential confounders, soy food intake was inversely associated with subsequent risk of lung cancer (P(trend) = 0.004); the hazard ratio for the highest quintile of intake compared with the lowest was 0.63 (95% confidence interval: 0.44, 0.90). This inverse association appeared predominately among women with later age at menopause (P(interaction) = 0.01) and for aggressive lung cancer as defined by length of survival (<12 months vs. ≥12 months; P(heterogeneity) = 0.057). Meta-analysis of 7 studies conducted among nonsmokers found a summary relative risk of 0.59 (95% confidence interval: 0.49, 0.71) for the highest categories of soy or isoflavone intake versus the lowest. This study suggests that soy food consumption may reduce lung cancer risk in nonsmoking women, particularly for aggressive tumors, and its effect may be modified by endogenous estrogens.
Authors:
Gong Yang; Xiao Ou Shu; Wong-Ho Chow; Xianglan Zhang; Hong-Lan Li; Bu-Tian Ji; Hui Cai; Shenghui Wu; Yu-Tang Gao; Wei Zheng
Related Documents :
22896645 - Food and fitness: associations between crop yields and life-history traits in a longitu...
16259425 - Improving urban air quality in china: beijing case study.
7344955 - Pattern recognition in radiographs of excised air-inflated human lungs. iii chronic int...
11347605 - Bioaccumulation of persistent organic pollutants in lichen-caribou-wolf food chains of ...
20694195 - Recruitment strategies and colony size in ants.
7604395 - Long vs. short monitoring intervals for peach harvesters exposed to foliar azinphos-met...
Publication Detail:
Type:  Journal Article; Meta-Analysis; Research Support, N.I.H., Extramural     Date:  2012-10-24
Journal Detail:
Title:  American journal of epidemiology     Volume:  176     ISSN:  1476-6256     ISO Abbreviation:  Am. J. Epidemiol.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-08     Completed Date:  2013-01-18     Revised Date:  2013-12-04    
Medline Journal Info:
Nlm Unique ID:  7910653     Medline TA:  Am J Epidemiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  846-55     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Aged
China / epidemiology
Eating
Female
Humans
Isoflavones / pharmacology
Lung Neoplasms / epidemiology*,  etiology,  pathology,  prevention & control
Middle Aged
Neoplasm Invasiveness
Proportional Hazards Models
Prospective Studies
Risk
Risk Factors
Soy Foods* / statistics & numerical data
Grant Support
ID/Acronym/Agency:
R37 CA070867/CA/NCI NIH HHS; R37CA070867/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Isoflavones
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Dual-source parallel RF transmission for diffusion-weighted imaging of the abdomen using different b...
Next Document:  Arsenic exposure, diabetes prevalence, and diabetes control in the Strong Heart Study.