Document Detail


Sox2 protects neural stem cells from apoptosis via up-regulating survivin expression.
MedLine Citation:
PMID:  23301561     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Transcriptional factor Sox2 is essential for regulation of self-renewal and homeostasis of neural stem cells (NSCs) during brain development. However, the downstream targets of Sox2 and the underlying molecular mechanism are largely unknown. In this study, we found that Sox2 directly up-regulates the expression of survivin, which inhibits the mitochondria-dependent apoptotic pathway in NSCs. While over-expression of Sox2 elevates the survivin expression, knock-down of Sox2 results in a decrease in survivin expression, thereby initiating the mitochondria-dependent apoptosis related with caspase-9 activation. Furthermore, cell apoptosis due to Sox2 knock-down can be rescued by ectopically expressing survivin in NSCs as well as in the mouse brain, as demonstrated by an in utero-injection approach. In short, we have found a novel Sox2-survivin pathway that regulates NSC survival and homeostasis, thus revealing a new mechanism of brain development, neurological degeneration and such aging-related disorders.
Authors:
Ruopeng Feng; Shixin Zhou; Yinan Liu; Daijun Song; Zhilin Luan; Xin Dai; Yang Li; Na Tang; Jinhua Wen; Lingsong Li
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-10
Journal Detail:
Title:  The Biochemical journal     Volume:  -     ISSN:  1470-8728     ISO Abbreviation:  Biochem. J.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2984726R     Medline TA:  Biochem J     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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