Document Detail


Sox10-iCreER(T2) : A mouse line to inducibly trace the neural crest and oligodendrocyte lineage.
MedLine Citation:
PMID:  22173870     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
SOX10 is a well-conserved and widely expressed transcription factor involved in the regulation of embryonic development and in the determination of cell fate. As it is expressed in neural crest cells, their derivatives and the oligodendrocyte lineage, mutations of the protein contribute to a variety of diseases like neurocristopathies, peripheral demyelinating neuropathies and melanoma. Here, we report the generation of an inducible Sox10-iCreER(T2) BAC transgenic mouse line that labels, depending on the timepoint of induction, distinct derivatives of the otic placode and the neural crest as well as cells of the oligodendrocyte lineage. Surprisingly, we could show a neural crest origin of pericytes in the brain. Besides its use for fate-mapping, the Sox10-iCreER(T2) mouse line is a powerful tool to conditionally inactivate genes in the neural crest cells, its progeny and/or the oligodendrocyte lineage in a time-dependent fashion to gain further insights into their function and contribution to diseases. © 2011 Wiley-Liss, Inc.
Authors:
Christiane Simon; Heiko Lickert; Magdalena Götz; Leda Dimou
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-12-15
Journal Detail:
Title:  Genesis (New York, N.Y. : 2000)     Volume:  -     ISSN:  1526-968X     ISO Abbreviation:  -     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-12-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100931242     Medline TA:  Genesis     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 Wiley-Liss, Inc.
Affiliation:
Physiological Genomics, Institute of Physiology, Ludwig-Maximilians University Munich, Germany; Institute for Stem Cell Research, HelmholtzZentrum münchen, Neuherberg, Germany.
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