Document Detail


Sox1 Maintains the Undifferentiated State of Cortical Neural Progenitor Cells Via the Suppression of Prox1-Mediated Cell Cycle Exit and Neurogenesis.
MedLine Citation:
PMID:  20973031     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Neural stem/progenitor cells maintain their identity via continuous self-renewal and suppression of differentiation. Gain-of-function experiments in the chick revealed an involvement for Sox1-3 transcription factors in the maintenance of the undifferentiated neural progenitor identity. However, the mechanism(s) employed by each factor has not been resolved. Here, we derived cortical neural/stem progenitor cells from wild type and Sox1-null mouse embryos and found that Sox1 plays a key role in the suppression of neurogenic cell divisions. Loss of Sox1 leads to progressive depletion of self-renewing cells, elongation of the cell cycle of proliferating cells and significant increase in the number of cells exiting the cell cycle. In proliferating neural progenitor cells, Sox1 acts via a Prox1-mediated pathway to block cell cycle exit that leads to neuronal differentiation in vivo and in vitro. Thus, our results demonstrate that Sox1 regulates the size of the cortical neural progenitor pool via suppression of Prox1-mediated neurogenic cell divisions.
Authors:
Maximilianos Elkouris; Nikos Balaskas; Maria Poulou; Panagiotis K Politis; Elena Panayiotou; Stavros Malas; Dimitra Thomaidou; Eumorphia Remboutsika
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2010-10-22
Journal Detail:
Title:  Stem cells (Dayton, Ohio)     Volume:  -     ISSN:  1549-4918     ISO Abbreviation:  -     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-10-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9304532     Medline TA:  Stem Cells     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Stem Cell Biology Laboratory, Institute of Molecular Biology and Genetics, BSRC Alexander Fleming, 34 Fleming, 16672 Vari-Attica, Greece.
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