Document Detail

Southern blot analysis of Bcr, N-ras, H-ras, c-myc and myb proto-oncogenes in blast crisis of chronic myelogenous leukemia.
MedLine Citation:
PMID:  2741649     Owner:  NLM     Status:  MEDLINE    
Proto-oncogenes were studied by Southern blotting in 12 patients with chronic myelogenous leukemia in blast crisis (CML). Cytogenetically, all cases had Philadelphia (Ph1) chromosome and 4 had additional chromosomal abnormalities including +8, +19, i(17q), double Ph1. The bcr gene was rearranged in all cases and the region of breakage points were located in the 5.8 kb Bgl II-Bam HI fragment of bcr. In a case with double Ph1 the breakage points of bcr were thought to be different from each other. We analyzed other proto-oncogenes (N-ras, H-ras, c-myc and myb) by Southern blotting, but did not find any abnormalities.
T Naoe; S Doi; K Yamanaka; K Naito; M Nitta; K Yamada
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Nihon Ketsueki Gakkai zasshi : journal of Japan Haematological Society     Volume:  52     ISSN:  0001-5806     ISO Abbreviation:  Nippon Ketsueki Gakkai Zasshi     Publication Date:  1989 Feb 
Date Detail:
Created Date:  1989-08-10     Completed Date:  1989-08-10     Revised Date:  2011-07-28    
Medline Journal Info:
Nlm Unique ID:  2984803R     Medline TA:  Nihon Ketsueki Gakkai Zasshi     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  32-7     Citation Subset:  IM    
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MeSH Terms
Blast Crisis*
Blotting, Southern
Chromosome Aberrations
Leukemia, Myelogenous, Chronic, BCR-ABL Positive / genetics*,  pathology
Middle Aged
Philadelphia Chromosome

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