Document Detail

South Asian men have different patterns of coronary artery disease when compared with European men.
MedLine Citation:
PMID:  18022712     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: To compare patterns of coronary artery disease in British South Asian and White European men. METHODS: 41 South Asian and 42 European men (mean age 64+/-9 years) with coronary artery disease were studied. All had similar symptoms. Vessel reference diameter and degree of stenosis were calculated using quantitative coronary angiography. Extent of atherosclerotic disease in the LAD was assessed using calcification scores (CAC) measured by multislice Computed Tomography. Fasting bloods and blood pressure were measured. The LAD was subdivided into four 2.5 cm segments for analysis. RESULTS: Most atherosclerosis occurred in the proximal LAD segment, South Asian men had more proximal LAD stenosis than European men (50% vs. 37%, p=0.036), but CAC scores were similar. South Asians with CAC scores in the lowest tertile (0-22 HU), had significantly narrower LAD diameters than Europeans (2.8 mm vs. 3.8 mm, p=0.004, adjusted for body surface area and age). This ethnic difference was not explained by measured risk factors, including diabetes. In contrast, ethnic differences in LAD diameter were abolished in the upper tertiles of CAC scores (23-2416 HU) (South Asians: 3.0 mm, Europeans: 3.1 mm, p=0.6). Calcification scores were negatively correlated with LAD diameter in Europeans (rho=-0.38, p=0.016) but not in South Asians (rho=-0.06, p=0.72). CONCLUSIONS: Increased LAD stenosis, despite equivalent levels of calcified disease, in South Asians is attributable to narrower arteries. Reduced LAD diameter is associated with advanced disease in Europeans but not in South Asians, indicative of ethnic differences in vascular remodelling.
Therese Tillin; Harshil Dhutia; John Chambers; Iqbal Malik; Emma Coady; Jamil Mayet; Andrew R Wright; Jaspal Kooner; Angela Shore; Simon Thom; Nish Chaturvedi; Alun Hughes
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-11-26
Journal Detail:
Title:  International journal of cardiology     Volume:  129     ISSN:  1874-1754     ISO Abbreviation:  Int. J. Cardiol.     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2010-02-23     Completed Date:  2010-09-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8200291     Medline TA:  Int J Cardiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  406-13     Citation Subset:  IM    
International Centre for Circulatory Health, St Mary's Hospital, Hammersmith Hospital and Imperial College, 59 North Wharf Road, London W2 1LA, UK.
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MeSH Terms
Asia, Southeastern / ethnology*
Coronary Artery Disease / ethnology*,  pathology*
Coronary Vessels / pathology*
European Continental Ancestry Group / ethnology*
Middle Aged
Prospective Studies
Grant Support
//British Heart Foundation

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