Document Detail

Source of pain and primitive dysfunction in migraine: an identical site?
MedLine Citation:
PMID:  2515254     Owner:  NLM     Status:  MEDLINE    
Twenty common migraine patients received a one sided frontotemporal application of nitroglycerin (10 patients) or placebo ointment (10 patients) in a double blind study. Early onset migraine attacks were induced by nitroglycerin in seven out of 10 patients versus no patient in the placebo group. Subsequently 20 migraine patients, who developed an early onset attack with frontotemporal nitroglycerin, received the drug in a second induction test at other body areas. No early onset migraine was observed. Thus the migraine-inducing effect of nitroglycerin seems to depend on direct stimulation of the habitual site of pain, suggesting that the frontotemporal region is of crucial importance in the development of a migraine crisis. This is not consistent with a CNS origin of migraine attack.
S Bonuso; E Marano; E di Stasio; F Sorge; F Barbieri; E A Ullucci
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Journal of neurology, neurosurgery, and psychiatry     Volume:  52     ISSN:  0022-3050     ISO Abbreviation:  J. Neurol. Neurosurg. Psychiatr.     Publication Date:  1989 Dec 
Date Detail:
Created Date:  1990-03-07     Completed Date:  1990-03-07     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  2985191R     Medline TA:  J Neurol Neurosurg Psychiatry     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1351-4     Citation Subset:  IM    
Department of Neurology, Second School of Medicine, University of Naples, Italy.
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MeSH Terms
Administration, Cutaneous
Double-Blind Method
Frontal Lobe / drug effects
Middle Aged
Migraine Disorders / chemically induced*
Nitroglycerin / administration & dosage*,  adverse effects
Randomized Controlled Trials as Topic
Temporal Lobe / drug effects
Reg. No./Substance:
0/Ointments; 55-63-0/Nitroglycerin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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