Document Detail


Source of extracellular brain adenosine during hypoxia in fetal sheep.
MedLine Citation:
PMID:  9459565     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Microdialysis was performed to determine whether hypoxia increases fetal brain adenosine (ADO) concentration through dephosphorylation of extracellular 5'-adenosine monophosphate (5-AMP). Hypoxia (fetal PaO2 approximately 14 Torr) increased fetal brain ADO levels approximately two-fold when the probes were perfused with synthetic cerebrospinal fluid (CSF) containing inhibitors of the nucleoside transporter but not with this solution plus a blocker of ecto-5'-nucleotidase (AOPCP). The hypoxia-induced rise in fetal brain ADO concentrations depends critically upon the hydrolysis of extracellular 5'-AMP.
Authors:
B J Koos; L Kruger; T F Murray
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Brain research     Volume:  778     ISSN:  0006-8993     ISO Abbreviation:  Brain Res.     Publication Date:  1997 Dec 
Date Detail:
Created Date:  1998-03-03     Completed Date:  1998-03-03     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  439-42     Citation Subset:  IM    
Affiliation:
Department of Obstetrics and Gynecology, Brain Research Institute, UCLA School of Medicine, Los Angeles, CA 90095-1740, USA.
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MeSH Terms
Descriptor/Qualifier:
Adenosine Diphosphate / analogs & derivatives,  antagonists & inhibitors,  metabolism
Adenosine Monophosphate / metabolism*
Animals
Cerebrospinal Fluid
Enzyme Inhibitors / metabolism
Female
Fetal Hypoxia / metabolism*
Microdialysis
Pregnancy
Respiration / physiology*
Sheep
Thalamus / chemistry,  enzymology
Grant Support
ID/Acronym/Agency:
DA-00217/DA/NIDA NIH HHS; HD-18478/HD/NICHD NIH HHS; NS-5685/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
0/Enzyme Inhibitors; 3768-14-7/adenosine 5'-methylenediphosphate; 58-64-0/Adenosine Diphosphate; 61-19-8/Adenosine Monophosphate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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