| Source of extracellular brain adenosine during hypoxia in fetal sheep. | |
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MedLine Citation:
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PMID: 9459565 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Microdialysis was performed to determine whether hypoxia increases fetal brain adenosine (ADO) concentration through dephosphorylation of extracellular 5'-adenosine monophosphate (5-AMP). Hypoxia (fetal PaO2 approximately 14 Torr) increased fetal brain ADO levels approximately two-fold when the probes were perfused with synthetic cerebrospinal fluid (CSF) containing inhibitors of the nucleoside transporter but not with this solution plus a blocker of ecto-5'-nucleotidase (AOPCP). The hypoxia-induced rise in fetal brain ADO concentrations depends critically upon the hydrolysis of extracellular 5'-AMP. |
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Authors:
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B J Koos; L Kruger; T F Murray |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Brain research Volume: 778 ISSN: 0006-8993 ISO Abbreviation: Brain Res. Publication Date: 1997 Dec |
Date Detail:
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Created Date: 1998-03-03 Completed Date: 1998-03-03 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0045503 Medline TA: Brain Res Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 439-42 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, Brain Research Institute, UCLA School of Medicine, Los Angeles, CA 90095-1740, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenosine Diphosphate
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analogs & derivatives,
antagonists & inhibitors,
metabolism Adenosine Monophosphate / metabolism* Animals Cerebrospinal Fluid Enzyme Inhibitors / metabolism Female Fetal Hypoxia / metabolism* Microdialysis Pregnancy Respiration / physiology* Sheep Thalamus / chemistry, enzymology |
| Grant Support | |
ID/Acronym/Agency:
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DA-00217/DA/NIDA NIH HHS; HD-18478/HD/NICHD NIH HHS; NS-5685/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Enzyme Inhibitors; 3768-14-7/adenosine 5'-methylenediphosphate; 58-64-0/Adenosine Diphosphate; 61-19-8/Adenosine Monophosphate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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