Document Detail

Sotalol-induced torsades de pointes in patients with renal failure.
MedLine Citation:
PMID:  9039065     Owner:  NLM     Status:  MEDLINE    
The risk of torsades de pointes in patients on sotalol is increased in the setting of renal failure. QT dispersion and prolonged QT intervals have been described as markers for pro-arrhythmia. Four cases of torsades de pointes caused by low dose sotalol in patients with renal failure are reported. All four cases demonstrated that the 12-lead electrocardiogram, with markedly prolonged QT intervals and increased QT dispersion, could have been used to predict pro-arrhythmia.
D Dancey; Z Wulffhart; P McEwan
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The Canadian journal of cardiology     Volume:  13     ISSN:  0828-282X     ISO Abbreviation:  Can J Cardiol     Publication Date:  1997 Jan 
Date Detail:
Created Date:  1997-03-07     Completed Date:  1997-03-07     Revised Date:  2008-04-09    
Medline Journal Info:
Nlm Unique ID:  8510280     Medline TA:  Can J Cardiol     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  55-8     Citation Subset:  IM    
Sunnybrook Health Science Centre, Toronto, Ontario.
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MeSH Terms
Adrenergic beta-Antagonists / adverse effects*
Aged, 80 and over
Anti-Arrhythmia Agents / adverse effects*
Kidney Failure / complications*,  therapy
Middle Aged
Peritoneal Dialysis
Renal Dialysis
Risk Factors
Sotalol / adverse effects*
Torsades de Pointes / chemically induced*
Reg. No./Substance:
0/Adrenergic beta-Antagonists; 0/Anti-Arrhythmia Agents; 3930-20-9/Sotalol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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