| Sorption of tylosin A, D, and A-aldol and degradation of tylosin A in soils. | |
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MedLine Citation:
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PMID: 17702335 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Heightened concerns regarding the potential impact on soil and water quality of veterinary antibiotics warrant a better understanding of the environmental fate of antibiotics in soil. Sorption of the macrolides tylosin A (TA), tylosin D, and TA-aldol was measured in several soils and evaluated with respect to soil pH, organic matter content, percentage clay, and cation-exchange capacity (CEC). Tylosin and related compounds exhibit similar sorption characteristics and generally are strongly sorbed, with sorption being well and positively correlated to surface area, clay content, and CEC. Sorption coefficients normalized by CEC were within a narrow range (10(4.1+/-0.21 L/molc) for all but one soil; however, good extraction recoveries with only methanol for most soils suggested that hydrophobic processes also contribute to sorption. Aerobic degradation of TA over a three-month period in two freshly collected agricultural soils and 60Co-irradiated soils indicated that both abiotic and microbial processes contribute to TA transformation. The abiotic process was much slower and dominated in the first two weeks, followed by rapid microbial degradation within 3 d. Three primary degradation products were identified using liquid chromatography with full-scan mass spectrometry, with unconfirmed identifications of TA having the aldehyde group oxidized to an acid (m/z = 932) in both soils and tyslosin B (m/z = 772) as well as tylosin B having the aldehyde group oxidized to an acid (m/z = 788) in the sandy soil. |
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Authors:
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Stephen A Sassman; Ajit K Sarmah; Linda S Lee |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Environmental toxicology and chemistry / SETAC Volume: 26 ISSN: 0730-7268 ISO Abbreviation: Environ. Toxicol. Chem. Publication Date: 2007 Aug |
Date Detail:
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Created Date: 2007-08-17 Completed Date: 2007-10-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8308958 Medline TA: Environ Toxicol Chem Country: United States |
Other Details:
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Languages: eng Pagination: 1629-35 Citation Subset: IM |
Affiliation:
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Department of Agronomy, Purdue University, West Lafayette, Indiana 47907, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aerobiosis Agriculture* Aldehydes / analysis, chemistry, metabolism* Anti-Bacterial Agents / analysis, chemistry, metabolism* Biodegradation, Environmental Chromatography, Liquid Hydrogen-Ion Concentration Hydrophobicity Mass Spectrometry Soil Microbiology* Soil Pollutants / analysis, chemistry, metabolism* Time Factors Tylosin / analysis, chemistry, metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Aldehydes; 0/Anti-Bacterial Agents; 0/Soil Pollutants; 107-89-1/3-hydroxybutanal; 1401-69-0/Tylosin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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