| Sorafenib in combination with transarterial chemoembolization improves survival of unresectable hepatocellular carcinoma: A propensity-score matching study. | |
| | |
MedLine Citation:
|
PMID: 23324079 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
OBJECTIVE: This prospective non-randomized controlled trial was aimed to compare the efficacy of sorafenib in combination with transarterial chemoembolization (TACE) versus TACE alone for treatment of patients with unresectable intermediate/advanced stage hepatocellular carcinoma (HCC). METHODS: A total of 304 patients were enrolled and all treated with TACE, 82 of the patients received concurrent sorafenib (400 mg orally twice daily initiated within 7 days after TACE), and these patients were matched with 164 patients who received TACE alone at a 1:2 ratio using propensity-score matching to minimize selection bias. The response to treatment, time-to-progression (TTP), overall survival (OS) as well as adverse effects were compared between the two groups. RESULTS: During a median follow-up period of 21.4 weeks (range 0.5-103 weeks), the addition of sorafenib improved TTP from 4.3 months to 6.3 months (hazard ratio [HR] 0.60, 95% CI 0.422-0.853, P = 0.004) and prolonged median survival time from 5.1 months to 7.5 months (HR 0.61, 95% CI 0.423-0.884, P = 0.009). Significant prognostic factors for OS by multivariate analyses included the use of sorafenib, BCLC stage, metastasis/vascular invasion, and liver function. CONCLUSIONS: The combined use of sorafenib and TACE was generally well-tolerated and significantly improved the overall survival, TTP, as compared to TACE alone. Further studies are warranted to confirm the safety and efficacy of this combination. |
| | |
Authors:
|
Wei Bai; Yong Ji Wang; Yan Zhao; Xing Shun Qi; Zhan Xin Yin; Chuang Ye He; Rui Jun Li; Kai Chun Wu; Jie Lai Xia; Dai Ming Fan; Guo Hong Han |
Related Documents
:
|
3667369 - Radiation therapy in early carcinoma of the true vocal cords (stage i and ii). 7237399 - Parameningeal rhabdomyosarcoma in the young. 23650219 - Treatment with topotecan plus cyclophosphamide in children with first relapse of neurob... 23106409 - Comparison with published systems of a new staging system for papillary and follicular ... 23591789 - A phase iii study of gemtuzumab ozogamicin during induction and post-consolidation ther... 23161409 - Phase ii study of cisplatin and oral vp16 in patients with refractory or relapsed ewing... 10473989 - Radical nephrectomy for renal cell carcinoma: is adrenalectomy necessary? 1572829 - Highly anaplastic astrocytoma: a review of 357 patients treated between 1977 and 1989. 22853619 - Multi-center randomized double-blind controlled clinical study of chemotherapy combined... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2013-1-17 |
Journal Detail:
|
Title: Journal of digestive diseases Volume: - ISSN: 1751-2980 ISO Abbreviation: J Dig Dis Publication Date: 2013 Jan |
Date Detail:
|
Created Date: 2013-1-17 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101302699 Medline TA: J Dig Dis Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
© 2013 The Authors. Journal of Digestive Diseases © 2013 Chinese Medical Association Shanghai Branch, Chinese Society of Gastroenterology, Renji Hospital Affiliated to Shanghai Jiaotong University School of Medicine and Wiley Publishing Asia Pty Ltd. |
Affiliation:
|
Department of Digestive Interventional Radiology, Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi'an, Shaanxi Province, China. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Effect of the Closure Type on the Evolution of the Physical-Chemical and Sensory Characteristics of ...
Next Document: JContextExplorer: a tree-based approach to facilitate cross-species genomic context comparison.