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Sorafenib in combination with transarterial chemoembolization improves survival of unresectable hepatocellular carcinoma: A propensity-score matching study.
MedLine Citation:
PMID:  23324079     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVE: This prospective non-randomized controlled trial was aimed to compare the efficacy of sorafenib in combination with transarterial chemoembolization (TACE) versus TACE alone for treatment of patients with unresectable intermediate/advanced stage hepatocellular carcinoma (HCC). METHODS: A total of 304 patients were enrolled and all treated with TACE, 82 of the patients received concurrent sorafenib (400 mg orally twice daily initiated within 7 days after TACE), and these patients were matched with 164 patients who received TACE alone at a 1:2 ratio using propensity-score matching to minimize selection bias. The response to treatment, time-to-progression (TTP), overall survival (OS) as well as adverse effects were compared between the two groups. RESULTS: During a median follow-up period of 21.4 weeks (range 0.5-103 weeks), the addition of sorafenib improved TTP from 4.3 months to 6.3 months (hazard ratio [HR] 0.60, 95% CI 0.422-0.853, P = 0.004) and prolonged median survival time from 5.1 months to 7.5 months (HR 0.61, 95% CI 0.423-0.884, P = 0.009). Significant prognostic factors for OS by multivariate analyses included the use of sorafenib, BCLC stage, metastasis/vascular invasion, and liver function. CONCLUSIONS: The combined use of sorafenib and TACE was generally well-tolerated and significantly improved the overall survival, TTP, as compared to TACE alone. Further studies are warranted to confirm the safety and efficacy of this combination.
Authors:
Wei Bai; Yong Ji Wang; Yan Zhao; Xing Shun Qi; Zhan Xin Yin; Chuang Ye He; Rui Jun Li; Kai Chun Wu; Jie Lai Xia; Dai Ming Fan; Guo Hong Han
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-17
Journal Detail:
Title:  Journal of digestive diseases     Volume:  -     ISSN:  1751-2980     ISO Abbreviation:  J Dig Dis     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101302699     Medline TA:  J Dig Dis     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2013 The Authors. Journal of Digestive Diseases © 2013 Chinese Medical Association Shanghai Branch, Chinese Society of Gastroenterology, Renji Hospital Affiliated to Shanghai Jiaotong University School of Medicine and Wiley Publishing Asia Pty Ltd.
Affiliation:
Department of Digestive Interventional Radiology, Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi'an, Shaanxi Province, China.
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