Document Detail

Sorafenib therapy for metastatic renal carcinoma in patients with low cardiac ejection fraction: report of two cases and literature review.
MedLine Citation:
PMID:  20014944     Owner:  NLM     Status:  MEDLINE    
Targeted therapies used in the treatment of metastatic renal cell carcinoma (RCC) are known to have the potential for cardiotoxicity and should be used with caution in patients with cardiac comorbidities. A retrospective review identified two RCC cases treated with sorafenib in the context of preexisting cardiomyopathy. Sorafenib therapy resulted in disease stabilization of progressing RCC for both cases, without worsening of cardiac ejection fraction. Further evaluation of the cardiac safety of sorafenib in patients with cardiomyopathy is warranted.
Pratima Kamada; Arkadiusz Z Dudek
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Cancer investigation     Volume:  28     ISSN:  1532-4192     ISO Abbreviation:  Cancer Invest.     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-05-10     Completed Date:  2010-05-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8307154     Medline TA:  Cancer Invest     Country:  England    
Other Details:
Languages:  eng     Pagination:  501-4     Citation Subset:  IM    
Department of Oncology, and Transplantation, University of Minnesota, Minneapolis, USA.
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MeSH Terms
Antineoplastic Agents / adverse effects*
Benzenesulfonates / adverse effects*
Carcinoma, Renal Cell / complications*,  drug therapy*,  pathology
Heart Diseases / complications*,  physiopathology
Kidney Neoplasms / complications*,  drug therapy*,  pathology
Middle Aged
Neoplasm Metastasis
Pyridines / adverse effects*
Stroke Volume*
Reg. No./Substance:
0/Antineoplastic Agents; 0/Benzenesulfonates; 0/Pyridines; 0/sorafenib

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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