Document Detail

Sonovue improves endocardial border detection and variability in assessing wall motion score and ejection fraction during stress echocardiography.
MedLine Citation:
PMID:  15732229     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Stress echocardiography is useful for assessing patients with coronary artery disease unable to undergo formal exercise testing. Considerable skill is required to avoid large intra- and inter-observer variability due to poor endocardial definition. Intravenous ultrasound contrast agents are now available which may improve this variability. AIM: To study intravenous Sonovue in assessing wall motion score and ejection fraction (EF) during stress echocardiography. METHODS: Thirty-eight patients undergoing arbutamine stress echocardiography for known or suspected coronary artery disease were studied. Echocardiographic analysis of wall motion score index, endocardial border detection (EBD) and EF was performed at rest and at peak stress before and after intravenous injection of Sonovue, by experienced and inexperienced observers. RESULTS: All three observers noted an improvement in endocardial border definition following Sonovue (p=<0.001). At baseline, there was a significant difference in wall motion score index between experienced and inexperienced observers at rest (p=0.01) and at peak stress (p=0.001). Following Sonovue administration this was no longer significant (p=0.07, p=0.114). Intra-observer variability of end diastolic, end systolic volumes (ESV) and EF improved following contrast (p<0.05) at rest and during stress. CONCLUSION: Sonovue significantly improved EBD and reduced intra-observer variability of EF at rest and during peak arbutamine infusion.
A S Brown; M Calachanis; C Evdoridis; J Hancock; S Wild; A Prasan; P Nihoyannopoulos; M J Monaghan
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Publication Detail:
Type:  Clinical Trial; Clinical Trial, Phase III; Journal Article; Multicenter Study    
Journal Detail:
Title:  Irish journal of medical science     Volume:  173     ISSN:  0021-1265     ISO Abbreviation:  Ir J Med Sci     Publication Date:    2004 Jan-Mar
Date Detail:
Created Date:  2005-02-28     Completed Date:  2005-04-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7806864     Medline TA:  Ir J Med Sci     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  13-7     Citation Subset:  IM    
Department of Cardiology, Beaumont Hospital, Dublin, Ireland.
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MeSH Terms
Echocardiography, Stress / methods*
Endocardium / ultrasonography
Image Enhancement*
Middle Aged
Myocardial Contraction
Phospholipids / administration & dosage,  diagnostic use*
Stroke Volume
Sulfur Hexafluoride / administration & dosage,  diagnostic use*
Reg. No./Substance:
0/Phospholipids; 0/contrast agent BR1; 2551-62-4/Sulfur Hexafluoride

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