| Sonothrombolysis for acute coronary syndromes: Opportunities and challenges. | |
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MedLine Citation:
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PMID: 19355272 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Percutanous interventions and pharmacological thrombolysis are the current options for treatment of acute coronary syndromes (ACS). The former is limited by its availability and the latter by its efficacy. Sonothrombolysis has been demonstrated to be effective in achieving tissue perfusion in the peripheral arteries as well as in cerebral arteries. Therefore, there is potential of using sonothrombolysis for the treatment of ACS. An ultrasound imaging and delivery system could overcome the issue of access while combining it with microbubbles and low dose thrombolytics could result in a high reperfusion rate. Furthermore, the direct effect of ultrasound on ishemic myocardium (release of nitric oxide and increase in myocardial blood flow despite total coronary occlusion) could be exploited to protect the myocardium until reperfusion has been achieved. The success of reperfusion could be assessed in real-time using microbubbles. In order to achieve these goals, we need to plan systematic in vitro and in vivo studies to better understand the mechanics of sonothrombolysis. We also need to develop 4D combined imaging and ultrasound delivery systems. Positive developments in this field can translate into a major impact on human health world wide. |
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Authors:
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Sanjiv Kaul |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of the Acoustical Society of America Volume: 125 ISSN: 1520-8524 ISO Abbreviation: J. Acoust. Soc. Am. Publication Date: 2009 Apr |
Date Detail:
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Created Date: 2009-04-09 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7503051 Medline TA: J Acoust Soc Am Country: United States |
Other Details:
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Languages: eng Pagination: 2679 Citation Subset: IM |
Affiliation:
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Cardiovascular Div., Oregon Health & Sci. Univ., Portland, OR 97239. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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