| Sonography of placental abnormalities and oligohydramnios in women with elevated alpha-fetoprotein levels: comparison with control subjects. | |
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MedLine Citation:
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PMID: 2476009 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To evaluate the relationship of placental and amniotic fluid findings to elevated maternal serum alpha-fetoprotein (MS-AFP) levels, we compared sonograms made between 18 and 24 weeks gestational age in 76 women with elevated MS-AFP levels with sonograms of a control group. Patients with fetal malformations, incorrect dates, twins, or lack of follow-up were excluded. Overall, 27 (36%) of 76 patients with elevated MS-AFP levels had placental or amniotic fluid abnormalities compared with only three (3%) of 87 control subjects. Significant differences (p less than .01) were noted in the frequency of periplacental hemorrhage (9% vs 0%), intraplacental sonolucencies greater than or equal to 1.5 cm in diameter (18% vs 3%) and moderate or severe oligohydramnios (17% vs 0%). More patients with elevated MS-AFP levels had placenta previa (4%) or placental thickness greater than or equal to 3.5 cm (12%) than did those in the control group (1% and 5%, respectively), although these differences did not reach statistical significance. Seven (26%) of the 27 patients had more than one abnormality. We conclude that placental and/or amniotic fluid abnormalities are frequently shown on sonograms in women who are examined because of elevated MS-AFP levels. |
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Authors:
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R B Kelly; D A Nyberg; L A Mack; J Fitzsimmons; S Uhrich |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: AJR. American journal of roentgenology Volume: 153 ISSN: 0361-803X ISO Abbreviation: AJR Am J Roentgenol Publication Date: 1989 Oct |
Date Detail:
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Created Date: 1989-10-12 Completed Date: 1989-10-12 Revised Date: 2008-02-15 |
Medline Journal Info:
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Nlm Unique ID: 7708173 Medline TA: AJR Am J Roentgenol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 815-9 Citation Subset: AIM; IM |
Affiliation:
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Department of Radiology, University of Washington Hospital, Seattle 98195. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amniotic Fluid* Female Humans Placenta / pathology Placenta Diseases / diagnosis* Pregnancy Ultrasonography* alpha-Fetoproteins / analysis* |
| Chemical | |
Reg. No./Substance:
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0/alpha-Fetoproteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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