Document Detail

Sonographic morphology and hyaluronan content of umbilical cords of healthy and Down syndrome fetuses in early gestation.
MedLine Citation:
PMID:  15113626     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To explore the sonographic vascular architecture and the hyaluronan amount and distribution of umbilical cords of healthy and trisomy 21 fetuses in early gestation. MATERIAL AND METHODS: Umbilical cord sonographic morphology and morphometry of 112 consecutive normal fetuses and 11 trisomy 21 fetuses were assessed between 10 and 15 weeks of gestation. The umbilical coiling index was defined as the reciprocal of the length of one complete coil measured in a longitudinal section of the umbilical cord. The umbilical coiling angle was defined as the maximum angle between the long axis of the umbilical cord and that of the umbilical arteries. Three umbilical cord samples obtained from Down syndrome fetuses and one from a healthy fetus after voluntary termination of pregnancy at 13 weeks of gestation were used for biochemical analysis. Quantitative hyualuronan content and tissue distribution was studied using fluorophore-assisted carbohydrate electrophoresis (FACE) analysis and staining methods using biotin-labeled hyaluronan-binding protein (bHABP), respectively. RESULTS: A significant correlation was present between gestational age and both the umbilical coiling index (r=-0.56, p<0.001) and the umbilical coiling angle (r=-0.43, p<0.001). The proportion of uncoiled umbilical cords was significantly higher in Down syndrome fetuses than in healthy fetuses [8/112 (7.1%) vs. 4/11 (36.4%), p<0.05]. Biochemical analysis demonstrated a higher amount and a different distribution of hyaluronan in trisomy 21 umbilical cords compared to healthy fetuses. CONCLUSION: The umbilical cord of Down syndrome fetuses in early gestation shows peculiar sonographic vascular features and quantitative alterations of the Wharton's jelly hyaluronan.
Luigi Raio; Fabio Ghezzi; Antonella Cromi; Emanuele Cereda; Alberto Passi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Early human development     Volume:  77     ISSN:  0378-3782     ISO Abbreviation:  Early Hum. Dev.     Publication Date:  2004 Apr 
Date Detail:
Created Date:  2004-04-28     Completed Date:  2004-12-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7708381     Medline TA:  Early Hum Dev     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  1-12     Citation Subset:  IM    
Department of Experimental and Clinical Biomedical Science (DSBSC), University of Insubria, Varese, Italy.
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MeSH Terms
Antigens, CD44
Down Syndrome / metabolism,  ultrasonography*
Gestational Age
Hyaluronic Acid / analysis*
Maternal Age
Reference Values
Ultrasonography, Prenatal*
Umbilical Cord / chemistry*,  ultrasonography*
Reg. No./Substance:
0/Antigens, CD44; 58-85-5/Biotin; 9004-61-9/Hyaluronic Acid

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