| Sonographic measurement of cervical length and fetal fibronectin testing in threatened preterm labor. | |
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MedLine Citation:
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PMID: 16526097 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: In women presenting with threatened preterm labor, both fetal fibronectin and sonographic measurement of cervical length have been shown to distinguish between true and false labor. The aim of this study was to determine whether the combination of both tests provides a better prediction than the individual tests alone. METHODS: We examined 195 women with singleton pregnancies presenting at 24-36 (median 31) weeks of gestation with regular and painful uterine contractions, intact membranes and cervical dilatation of less than 3 cm. On admission to the hospital fetal fibronectin positivity in cervicovaginal secretions was determined and transvaginal sonographic measurement of cervical length was carried out. The results were not made available to the attending obstetrician. The primary outcome measure was delivery within 7 days of presentation. RESULTS: Delivery within 7 days occurred in 51.4% (18 of 35) of those with cervical length below 15 mm and 0.6% (1 of 160) of those with cervical length of 15 mm or more, in 21.2% (18 of 85) of the fibronectin positive group and in 0.9% (1 of 110) of the fibronectin negative group. There was a significant association between cervical length and the incidence of fibronectin positivity (r = -0.921, P = 0.003). Logistic regression analysis demonstrated that the only significant contributor to the prediction of delivery within 7 days was cervical length, with no significant contribution from fibronectin positivity, ethnic origin, maternal age, gestational age, body mass index, parity, previous history of preterm delivery, cigarette smoking, or use of tocolytics. CONCLUSIONS: In women with threatened preterm labor assessment of fetal fibronectin in cervicovaginal secretions does not improve the prediction of delivery within 7 days provided by the sonographic measurement of cervical length. |
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Authors:
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E Tsoi; S Akmal; L Geerts; B Jeffery; K H Nicolaides |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology Volume: 27 ISSN: 0960-7692 ISO Abbreviation: Ultrasound Obstet Gynecol Publication Date: 2006 Apr |
Date Detail:
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Created Date: 2006-04-03 Completed Date: 2006-12-05 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9108340 Medline TA: Ultrasound Obstet Gynecol Country: England |
Other Details:
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Languages: eng Pagination: 368-72 Citation Subset: IM |
Copyright Information:
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Copyright 2006 ISUOG. |
Affiliation:
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Harris Birthright Research Centre for Fetal Medicine, King's College Hospital, London, UK. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Biological Markers / blood Body Mass Index Cervix Uteri / ultrasonography* Continental Population Groups Female Fibronectins / blood* Gestational Age Glycoproteins / blood* Humans Logistic Models Maternal Age Obstetric Labor, Premature / diagnosis* Parity Pregnancy Pregnancy Trimester, Third ROC Curve Recurrence Regression Analysis Risk Assessment Sensitivity and Specificity Ultrasonography, Prenatal* |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/FFN protein, human; 0/Fibronectins; 0/Glycoproteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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