Document Detail


Sonographic markers for early diagnosis of fetal malformations.
MedLine Citation:
PMID:  24179631     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
Fetal malformations are very frequent in industrialized countries. Although advanced maternal age may affect pregnancy outcome adversely, 80%-90% of fetal malformations occur in the absence of a specific risk factor for parents. The only effective approach for prenatal screening is currently represented by an ultrasound scan. However, ultrasound methods present two important limitations: the substantial absence of quantitative parameters and the dependence on the sonographer experience. In recent years, together with the improvement in transducer technology, quantitative and objective sonographic markers highly predictive of fetal malformations have been developed. These markers can be detected at early gestation (11-14 wk) and generally are not pathological in themselves but have an increased incidence in abnormal fetuses. Thus, prenatal ultrasonography during the second trimester of gestation provides a "genetic sonogram", including, for instance, nuchal translucency, short humeral length, echogenic bowel, echogenic intracardiac focus and choroid plexus cyst, that is used to identify morphological features of fetal Down's syndrome with a potential sensitivity of more than 90%. Other specific and sensitive markers can be seen in the case of cardiac defects and skeletal anomalies. In the future, sonographic markers could limit even more the use of invasive and dangerous techniques of prenatal diagnosis (amniocentesis, etc.).
Authors:
Maria Daniela Renna; Paola Pisani; Francesco Conversano; Emanuele Perrone; Ernesto Casciaro; Gian Carlo Di Renzo; Marco Di Paola; Antonio Perrone; Sergio Casciaro
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  World journal of radiology     Volume:  5     ISSN:  1949-8470     ISO Abbreviation:  World J Radiol     Publication Date:  2013 Oct 
Date Detail:
Created Date:  2013-11-01     Completed Date:  2014-06-24     Revised Date:  2014-06-24    
Medline Journal Info:
Nlm Unique ID:  101538184     Medline TA:  World J Radiol     Country:  China    
Other Details:
Languages:  eng     Pagination:  356-71     Citation Subset:  -    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Real-time dosimetry in external beam radiation therapy.
Next Document:  Contrast-enhanced ultrasonography in peripheral lung consolidations: What's its actual role?