| Sonographic markers of aneuploidies at 6-10weeks of gestation. | |
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MedLine Citation:
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PMID: 21592687 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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OBJECTIVES: To determine if sonographic features of live embryos at 6-10weeks' gestation are altered in aneuploidies. METHODS: Embryonic crown rump length (CRL), embryonic heart rate, gestational sac diameter (GSD) and yolk sac diameter (YSD) were measured by transvaginal sonography in 5603 live embryos from singleton pregnancies at 6-10weeks' gestation. The measurements were expressed as differences from the expected normal mean for CRL (delta values) and median delta values in the aneuploid cases were compared to the euploid group. RESULTS: 5393 pregnancies resulted in the live birth of phenotypically normal neonates and these cases constituted the euploid group. In 55 cases there was subsequent prenatal diagnosis of aneuploidies (trisomy 21, n=28; trisomy 18, n=10; trisomy 13, n=10; triploidy, n=4; Turner syndrome, n=3). The median and interquartile range (IQR) of delta embryonic heart rate in trisomy 18 was -19.44 (-23.77 to -7.20)bpm and in trisomy 13 it was 11.12 (7.25 to 20.39)bpm, which were significantly lower and higher, respectively, than in euploid embryos (median -0.05, IQR -6.18 to 6.21bpm). The median delta YSD in trisomy 21 was higher than in euploid fetuses (median 0.56, IQR 0.23 to 0.79 and median -0.17, IQR -3.11 to 2.82mm). There were no other significant differences in measurements between the groups. CONCLUSION: At 6-10weeks' gestation there are sonographically detectable differences between euploid and trisomic embryos. |
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Authors:
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George K I Papaioannou; Argyro Syngelaki; Nerea Maiz; Jackie A Ross; Kypros H Nicolaides |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-5-17 |
Journal Detail:
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Title: Early human development Volume: - ISSN: 1872-6232 ISO Abbreviation: - Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-5-19 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7708381 Medline TA: Early Hum Dev Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011. Published by Elsevier Ireland Ltd. |
Affiliation:
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Fetal Medicine Unit, King's College Hospital, London, SE5 9RS, UK; Early Pregnancy Unit, King's College Hospital, London, SE5 9RS, UK. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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