Document Detail

Sonographic findings in severe fetomaternal transfusion.
MedLine Citation:
PMID:  19462175     Owner:  NLM     Status:  MEDLINE    
Fetomaternal hemorrhage (FMH) or fetomaternal transfusion syndrome is the leakage of fetal red blood cells into the maternal circulation. Massive FMH can cause substantial fetal morbidity and mortality. Sonographic evidence of severe FMH syndrome includes fetal hydrops and other fetal anemia-related findings. The peak systolic velocity in the middle cerebral artery has extensively been used for the prediction of fetal anemia and for the timing of the first intrauterine intravascular transfusion (IIVT). We present a case of severe FMH syndrome that was diagnosed during the 24th week of pregnancy. A total of eight IIVT were performed. The actual increase in the fetal Hb after each transfusion was much lower than the expected. At 27 weeks of gestation, sonographic evaluation revealed areas of echogenicity around the posterior horns of the lateral ventricles suggesting ischemic damage. Due to these findings, no further IIVTs were offered and the fetus died a week later. The management of fetal anemia caused by severe FMH is difficult, and the anemic fetuses do not respond well to serial IIVTs as the transfer of blood to the maternal circulation continues.
S Sifakis; O Koukoura; A E Konstantinidou; K Kikidi; M Prezerakou; P Kaminopetros
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2009-05-22
Journal Detail:
Title:  Archives of gynecology and obstetrics     Volume:  281     ISSN:  1432-0711     ISO Abbreviation:  Arch. Gynecol. Obstet.     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2009-12-25     Completed Date:  2010-04-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8710213     Medline TA:  Arch Gynecol Obstet     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  241-5     Citation Subset:  IM    
Department of Obstetrics and Gynecology, University Hospital of Heraklion, 71201, Heraklion, Crete, Greece.
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MeSH Terms
Blood Transfusion, Intrauterine / standards*
Fetal Death
Fetomaternal Transfusion / therapy,  ultrasonography*
Hemoglobins / analysis
Reg. No./Substance:

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