Document Detail

Sonographic and electrodiagnostic evaluations in patients with aromatase inhibitor-related arthralgia.
MedLine Citation:
PMID:  19752344     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To investigate the prevalence of arthralgia in breast cancer patients taking aromatase inhibitors (AIs) and perform a detailed rheumatologic assessment including autoimmune serology, musculoskeletal sonography, and electromyography (EMG) in these patients. PATIENTS AND METHODS: Postmenopausal patients with stage I to III breast cancer who were taking adjuvant AIs were enrolled (n = 92). Patients who were not receiving hormone treatment were included as a control group (n = 28). Musculoskeletal sonography and EMG were applied to the patients and the controls along with markers of autoimmunity. RESULTS: Thirty patients (32.6%) reported to have AI-related new-onset or worsening arthralgia. The most commonly affected joints were knee (70%), wrist (70%), and small joints of the hand (63%). Patients taking AIs had increased tendon thicknesses compared with those who never received AIs (P < .001). Patients with AI-related arthralgia had higher rates of effusion in hand joints/tendons than those without arthralgia (P = .033). More patients with AI-related arthralgia had EMG findings consistent with carpal tunnel syndrome (CTS) than those without arthralgia (P = .024). No significant difference was observed in erythrocyte sedimentation rates, C-reactive protein, antinuclear antibody, antidouble stranded DNA antibody, rheumatoid factor, or anticyclic citrullinated peptide levels between patients and controls or between those with and without arthralgia. CONCLUSION: Patients with AI-related arthralgia often show tenosynovial changes suggesting tenosynovitis, exerting local problems but lacking a systemic inflammatory component. Our finding of increased CTS frequency also supports this hypothesis.
Omer Dizdar; Levent Ozçakar; Fevziye Unsal Malas; Hakan Harputluoglu; Nilufer Bulut; Sercan Aksoy; Yavuz Ozisik; Kadri Altundag
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Publication Detail:
Type:  Journal Article     Date:  2009-09-14
Journal Detail:
Title:  Journal of clinical oncology : official journal of the American Society of Clinical Oncology     Volume:  27     ISSN:  1527-7755     ISO Abbreviation:  J. Clin. Oncol.     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-10-19     Completed Date:  2009-11-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8309333     Medline TA:  J Clin Oncol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  4955-60     Citation Subset:  IM    
Hacettepe University Institute of Oncology, Department of Medical Oncology, Ankara, Turkey.
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MeSH Terms
Aromatase Inhibitors / adverse effects*,  therapeutic use
Arthralgia / chemically induced*,  diagnosis*,  epidemiology
Breast Neoplasms / drug therapy*
Middle Aged
Prospective Studies
Reg. No./Substance:
0/Aromatase Inhibitors
Comment In:
J Clin Oncol. 2009 Oct 20;27(30):4932-4   [PMID:  19752332 ]

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