Document Detail

Sonographic detection of the optic radiation.
MedLine Citation:
PMID:  16299877     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To describe a region of hyperechoic white matter adjacent to the atrium of the lateral ventricle of preterms, and to speculate on the relevance of detecting preterm white matter injury. PATIENTS AND METHODS: Cranial ultrasound images of 92 preterms of gestational age (GA) 32 wk or less were reviewed. For each infant, one first week standard coronal image was used for measurement of grey values around the para-atrial region of interest (PAROI) relative to the choroid plexus. For verification of the sonographic anatomy, MR images of an adult brain were used. For reference, neuro-anatomical images were compared in several atlases. In a group of nine preterms of similar GA with cystic periventricular leukomalacia (PVL) or MR-confirmed white matter disease, the disappearance of the PAROI was examined. RESULTS: The hyperechoic para-atrial area, subjectively detected in 84% of the patients, was situated bilaterally between the inner end of the lateral fissure and the upper third of the choroid plexus. In white matter caudal to the atrium, the hyperechoic band could be pursued towards the calcarine area. The average ratio of grey value around the PAROI to the choroid plexus was 0.787 (SD = 0.072, median 0.791). There was no correlation between PAROI grey value and gestational age. At 26 wk gestational age, the average ratio was 0.781 (n = 14), and 0.789 (n = 17) at 31 wk. Location of the PAROI agrees with the angle of the upper loop of the optic radiation. None of the nine infants with white matter damage had PAROIs clearly distinguishable from flaring. CONCLUSION: The symmetrical and unchanged acoustic character between 26 and 31 wk of gestational age argues in favour of the hypothesis that the PAROI is an anatomical structure. The localization of the hyperechoic band supports the hypothesis that it represents part of the optic radiation. Further study is needed to examine the absence of a hyperechoic para-atrial band as a prognostic marker of the extension and severity of white matter injury.
Annemieke Boxma; Maarten Lequin; Luca A Ramenghi; Max Kros; Paul Govaert
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Acta paediatrica (Oslo, Norway : 1992)     Volume:  94     ISSN:  0803-5253     ISO Abbreviation:  Acta Paediatr.     Publication Date:  2005 Oct 
Date Detail:
Created Date:  2005-11-15     Completed Date:  2006-08-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9205968     Medline TA:  Acta Paediatr     Country:  Norway    
Other Details:
Languages:  eng     Pagination:  1455-61     Citation Subset:  IM    
Neonatal Intensive Care Unit, Sophia Children's Hospital, Rotterdam, The Netherlands.
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MeSH Terms
Brain Diseases / diagnosis
Chorioamnionitis / ultrasonography*
Choroid Plexus / ultrasonography*
Cohort Studies
Diagnosis, Differential
Fetal Development / physiology
Gestational Age
Infant, Newborn
Infant, Premature
Infant, Premature, Diseases / ultrasonography*
Intensive Care Units, Neonatal
Lateral Ventricles / ultrasonography*
Leukomalacia, Periventricular / pathology,  ultrasonography*
Magnetic Resonance Imaging
Observer Variation
Sensitivity and Specificity
Ultrasonography, Doppler

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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