| Sonographic blood flow measurements in malignant breast tumors. A potential new prognostic factor. | |
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MedLine Citation:
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PMID: 9294282 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The aim of this study was to find a possible relationship between the biological behavior of carcinomas of the breast and sonographically detectable blood flow after first studies showed a correlation between blood flow and prognostic factors. METHOD: 259 patients with ductal invasive breast cancer were examined using MEM (i.e., the Maximum Entropy Method), a new sonographic blood flow measurement technique capable of discerning considerably slower blood flow velocities than Doppler sonography. Due to the lack of objective methods for quantifying the blood flow, the findings were divided into three classes dependent upon the visual color information obtained. The blood flow was correlated with the size of the tumor, lymph node and receptor status, ploidy and S-phase fraction. RESULTS: Most of the patients with small tumors, without lymph node metastases, with positive receptors, with a diploid genome, and with a low S-phase fraction belonged to the group with the lowest blood flow. CONCLUSION: The close relationship between the established prognostic factors and the sonographic blood flow measurements using MEM might be indicative of a new preoperative prognostic factor; this must, however, be confirmed by larger studies. |
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Authors:
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C Sohn; F Beldermann; G Bastert |
Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article |
Journal Detail:
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Title: Surgical endoscopy Volume: 11 ISSN: 0930-2794 ISO Abbreviation: Surg Endosc Publication Date: 1997 Sep |
Date Detail:
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Created Date: 1997-09-30 Completed Date: 1997-09-30 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8806653 Medline TA: Surg Endosc Country: GERMANY |
Other Details:
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Languages: eng Pagination: 957-60 Citation Subset: IM |
Affiliation:
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Department for Prenatal and Gynecological Ultrasound Diagnosis and Treatment, Clinic of OB/GYN, University of Heidelberg, Heidelberg, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Blood Flow Velocity Breast / blood supply Breast Neoplasms / blood supply*, genetics, pathology, surgery, ultrasonography* Carcinoma, Ductal, Breast / blood supply*, genetics, pathology, secondary, surgery, ultrasonography* DNA, Neoplasm / analysis Diagnosis, Differential Female Humans Lymphatic Metastasis Ploidies Prognosis Receptors, Estrogen / analysis Receptors, Progesterone / analysis Regional Blood Flow S Phase Sensitivity and Specificity Ultrasonography, Doppler, Color / methods* |
| Chemical | |
Reg. No./Substance:
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0/DNA, Neoplasm; 0/Receptors, Estrogen; 0/Receptors, Progesterone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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