| Sonographic Measurement of Mesenteric Fat Predicts Presence of Fatty Liver among Subjects with Polycystic Ovary Syndrome. | |
| | |
MedLine Citation:
|
PMID: 21190980 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Objective: Visceral fat is believed to be important in the pathogenesis of metabolic syndrome and fatty liver. In this study, we examined the relationship between mesenteric fat thickness and other sonographic indices of adiposity and the presence of fatty liver among subjects with polycystic ovary syndrome (PCOS). Subjects and Methods: A total of 117 Chinese subjects with PCOS were evaluated (mean age, 28.6 ± 6.5 yr; mean body mass index, 24.3 ± 5.3 kg/m(2)). Anthropometric measurements and metabolic risk profile, including a standard oral glucose tolerance test, were assessed in all subjects. All subjects underwent an ultrasound examination for measurement of thickness of mesenteric, preperitoneal, and sc fat as well as evaluation for fatty liver. Results: Forty-six (39.3%) of the subjects had fatty liver. PCOS subjects with fatty liver had higher body mass index, waist circumference, waist-hip ratio, and systolic blood pressure; a more unfavorable lipid profile with higher triglyceride; lower high-density lipoprotein cholesterol; higher fasting glucose and insulin; higher 2-h glucose during oral glucose tolerance test; lower SHBG; and higher alanine aminotransferase. Subjects with fatty liver had increased thickness of preperitoneal, mesenteric, and sc fat, as well as increased carotid intima-media thickness. Abdominal fat thickness showed moderate correlation to alanine aminotransferase as well as fasting insulin. On multivariate logistic regression, fasting insulin and mesenteric fat thickness were identified as independent predictors of fatty liver among subjects with PCOS. Conclusion: Fatty liver is present in a significant proportion of Chinese patients with PCOS. Sonographic measurement of mesenteric fat is an independent determinant of fatty liver among subjects with PCOS and identifies subjects at increased cardiovascular risk. |
| | |
Authors:
|
R C W Ma; K H Liu; P M Lam; L P Cheung; W H Tam; G T C Ko; M H M Chan; C S Ho; C W K Lam; W C W Chu; P C Y Tong; W Y So; J C N Chan; C C Chow |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2010-12-29 |
Journal Detail:
|
Title: The Journal of clinical endocrinology and metabolism Volume: - ISSN: 1945-7197 ISO Abbreviation: - Publication Date: 2010 Dec |
Date Detail:
|
Created Date: 2010-12-30 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0375362 Medline TA: J Clin Endocrinol Metab Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Department of Medicine and Therapeutics (R.C.W.M., G.T.C.K., P.C.Y.T., W.Y.S., J.C.N.C., C.C.C.), Department of Imaging and Interventional Radiology (K.H.L., W.C.W.C.), Department of Obstetrics and Gynecology (P.M.L., L.P.C., W.H.T.), Department of Chemical Pathology (L.P.C., M.H.M.C., C.S.H., C.W.K.L.), and Hong Kong Institute of Diabetes and Obesity (R.C.W.M., P.C.Y.T., J.C.N.C.), The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Bone Morphogenetic Protein 15 (BMP15)/Growth Differentiating Factor 9 Heterodimer Is More Potent tha...
Next Document: Pubertal presentation in seven patients with congenital adrenal hyperplasia due to P450 oxidoreducta...