| Sonodynamically induced effect of rose bengal on isolated sarcoma 180 cells. | |
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MedLine Citation:
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PMID: 10100594 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: The ultrasonically induced effect of rose bengal (RB) on isolated tumor cells was investigated. METHODS: Sarcoma 180 cells were suspended in air-saturated phosphate-buffered saline and exposed to ultrasound in standing wave mode for up to 60 s in the presence and absence of RB. Cell viability was determined by the ability to exclude trypan blue. RESULTS: The rate of inducing cell damage by ultrasound was enhanced two to three times with 160 microM RB. while no cell damage was observed with RB alone. This enhancement was significantly inhibited by histidine. CONCLUSIONS: Ultrasonically induced in vitro cell damage was significantly enhanced by RB. A sonochemical mechanism may be suggested since the enhancement was significantly inhibited by an active oxygen scavenger. |
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Authors:
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S Umemura; N Yumita; K Umemura; R Nishigaki |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Cancer chemotherapy and pharmacology Volume: 43 ISSN: 0344-5704 ISO Abbreviation: Cancer Chemother. Pharmacol. Publication Date: 1999 |
Date Detail:
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Created Date: 1999-04-13 Completed Date: 1999-04-13 Revised Date: 2005-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7806519 Medline TA: Cancer Chemother Pharmacol Country: GERMANY |
Other Details:
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Languages: eng Pagination: 389-93 Citation Subset: IM |
Affiliation:
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Central Research Laboratory, Hitachi, Ltd., Tokyo, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Survival / drug effects Coloring Agents Drug Antagonism Fluorescent Dyes / pharmacology Histidine / pharmacology Humans Male Mice Mice, Inbred ICR Rose Bengal / pharmacology* Sarcoma 180 / pathology* Trypan Blue Ultrasonics* |
| Chemical | |
Reg. No./Substance:
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0/Coloring Agents; 0/Fluorescent Dyes; 11121-48-5/Rose Bengal; 71-00-1/Histidine; 72-57-1/Trypan Blue |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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