Document Detail

Sonodynamic and photodynamic therapy in advanced breast carcinoma: a report of 3 cases.
MedLine Citation:
PMID:  19815599     Owner:  NLM     Status:  MEDLINE    
Photodynamic therapy (PDT) is an established therapeutic method, first approved by the FDA for certain kinds of cancer in 1998. There are also increasing data to show that a related procedure, sonodynamic therapy (SDT), is a promising new modality for cancer treatment. Here, the authors report clinical results in 3 advanced refractory breast cancer patients who were treated using a combination of sonodynamic and photodynamic therapy (SPDT), along with conventional therapies. All 3 patients had pathologically proven metastatic breast carcinoma. These widely disseminated carcinomas had ultimately failed to respond to conventional therapy. A new sensitizing agent, Sonoflora 1 (SF1) was administered sublingually; then, after a 24-hour delay, patients were treated with a combination of light and ultrasound. All patients had significant partial or complete responses. SPDT is a promising new therapeutic combination for the treatment of breast cancer.
Xiaohuai Wang; Weimin Zhang; Zhiyong Xu; Yifan Luo; Doug Mitchell; Ralph W Moss
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Integrative cancer therapies     Volume:  8     ISSN:  1552-695X     ISO Abbreviation:  Integr Cancer Ther     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2009-10-09     Completed Date:  2010-03-12     Revised Date:  2010-12-10    
Medline Journal Info:
Nlm Unique ID:  101128834     Medline TA:  Integr Cancer Ther     Country:  United States    
Other Details:
Languages:  eng     Pagination:  283-7     Citation Subset:  IM    
Chemistry and Environment College, Southern China Normal University, Guangzhou, People's Republic of China.
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MeSH Terms
Administration, Sublingual
Breast Neoplasms / diagnosis,  pathology,  therapy*
Carcinoma / diagnosis,  pathology,  therapy*
Chlorophyll / analogs & derivatives,  therapeutic use
Combined Modality Therapy / methods
Complementary Therapies / instrumentation,  methods*
Fatal Outcome
Middle Aged
Neoplasm Metastasis / diagnosis,  pathology,  therapy
Photochemotherapy / instrumentation,  methods*
Photosensitizing Agents / administration & dosage,  therapeutic use
Positron-Emission Tomography
Treatment Outcome
Ultrasonic Therapy / instrumentation,  methods*
Reg. No./Substance:
0/Photosensitizing Agents; 1406-65-1/Chlorophyll
Comment In:
Integr Cancer Ther. 2010 Dec;9(4):317-9; discussion 320-1   [PMID:  21106611 ]

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