| Sonodynamic Effect of an Anti-inflammatory Agent - Emodin on Macrophages. | |
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MedLine Citation:
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PMID: 21767904 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Emodin has been used as an anti-inflammatory agent and inflammation is a crucial feature of atherosclerosis. Here, we investigated the sonodynamic effect of emodin on macrophages, the pivotal inflammatory cells in atherosclerotic plaque. THP-1 derived macrophages were cultured with emodin and exposed to ultrasound. Six hours later, unlike the cells treated for 5 and 10 min, the viability of cells treated for 15 min decreased significantly and the cells showed typical apoptotic chromatin fragmentation. The percentage of apoptotic and necrotic cells in the sonodynamic therapy (SDT) group was higher than that in the ultrasound group. Two hours after treatment for 15 min, the cytoskeleton lost its original features as the filaments dispersed and the cytoskeletal proteins aggregated. The percentage of cells with disturbed cytoskeletal filaments in the SDT group was higher than that in the ultrasound group. These results suggest emodin has a sonodynamic effect on macrophages and might be used as a novel sonosensitizer for SDT for atherosclerosis. |
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Authors:
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Qianping Gao; Fengping Wang; Shuyuan Guo; Jingyi Li; Bidan Zhu; Jiali Cheng; Yinghua Jin; Bo Li; Huan Wang; Sa Shi; Qiang Gao; Zhiguo Zhang; Wenwu Cao; Ye Tian |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-7-16 |
Journal Detail:
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Title: Ultrasound in medicine & biology Volume: - ISSN: 1879-291X ISO Abbreviation: - Publication Date: 2011 Jul |
Date Detail:
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Created Date: 2011-7-19 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0410553 Medline TA: Ultrasound Med Biol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 World Federation for Ultrasound in Medicine & Biology. Published by Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Pathophysiology, Harbin Medical University, Harbin, P. R. China; The First Affiliated Hospital of Harbin Medical University, Harbin, P. R. China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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