Document Detail

Sonicated albumin in exercise echocardiography: technique and feasibility to enhance endocardial visualization.
MedLine Citation:
PMID:  8827629     Owner:  NLM     Status:  MEDLINE    
Left ventricular cavity opacification can be produced by the intravenous injection of sonicated albumin (Albunex 422). A recent study suggested that sonicated albumin may be useful in dobutamine stress echocardiography, but its use in exercise echocardiography has not been reported. The purposes of the study were to assess the feasibility of using Albunex to enhance endocardial visualization and to evaluate the factors affecting Albunex kinetic in exercise echocardiography. Fifteen healthy volunteers underwent two exercise echocardiograms on the same day, with intravenous injection of Albunex during one of the studies. Two injections up to a maximum of 20 ml of Albunex per injection were given to enhance the four- and two-chamber views, both at rest and immediately after exercise. The degree of left ventricular enhancement and the percentages of endocardial visualization were measured in both resting and exercise images. Variables relating to the kinetics of Albunex, which included volume of contrast injected, transit time, heart rate, and cardiac output at the time of image acquisition, were also assessed. There was no difference in the image acquisition time between the two exercise echocardiograms. Albunex produced good left ventricular opacification both at rest and after exercise. More endocardial border was visualized with contrast injection than without (91.2% +/- 11.5% vs 85.8% +/- 14.2%, p = 0.007). The transit times and volumes of Albunex injected were significantly less after exercise than at rest. The parameters were inversely related to heart rate and cardiac output. In conclusion, intravenous injection of Albunex is a promising means to enhance left ventricular endocardial visualization in exercise echocardiography and can be readily incorporated without causing a significant delay in obtaining images after exercise. Whether its use can improve diagnostic accuracy of exercise echocardiography requires further studies.
K J Yvorchuk; R A Sochowski; K L Chan
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography     Volume:  9     ISSN:  0894-7317     ISO Abbreviation:  J Am Soc Echocardiogr     Publication Date:    1996 Jul-Aug
Date Detail:
Created Date:  1996-12-11     Completed Date:  1996-12-11     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8801388     Medline TA:  J Am Soc Echocardiogr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  462-9     Citation Subset:  IM    
Division of Cardiology, University of Ottawa Heart Institute, Ontario, Canada.
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MeSH Terms
Albumins / administration & dosage,  diagnostic use*,  pharmacokinetics
Contrast Media* / administration & dosage,  pharmacokinetics
Echocardiography / methods*
Endocardium / ultrasonography*
Exercise Test
Feasibility Studies
Heart Ventricles / ultrasonography
Injections, Intravenous
Reg. No./Substance:
0/Albumins; 0/Albunex; 0/Contrast Media

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