Document Detail


Sonic hedgehog signaling promotes growth of oral squamous cell carcinoma cells associated with bone destruction.
MedLine Citation:
PMID:  21945071     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Sonic hedgehog (Shh) and its signaling have been identified in several human cancers, and increased levels of its expression appear to correlate with disease progression and metastasis. However, the role of Shh in bone destruction associated with oral squamous cell carcinomas, which frequently invade the maxilla or the mandible, is still unclear. In this study we show that the use of siRNA for Shh to block SHH secreted by SAS oral squamous cell carcinoma cells suppressed the tumor growth and tumor angiogenesis of subcutaneous SAS xenografts in vivo. Moreover, blockade of Shh in SAS cells decreased tumor growth and osteoclast number in a tibial metaphysis mouse model. Significantly, we clearly show that SHH stimulated osteoclast formation in a co-culture system consisting of murine bone stromal ST2 cells and murine CD11b(+) bone marrow cells. These findings suggest that Shh signaling is a potential target for the treatment of oral squamous cell carcinoma associated with bone destruction.
Authors:
Tatsuki Honami; Tsuyoshi Shimo; Tatsuo Okui; Naito Kurio; Nur Mohammad Monsur Hassan; Masahiro Iwamoto; Akira Sasaki
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-09-25
Journal Detail:
Title:  Oral oncology     Volume:  48     ISSN:  1879-0593     ISO Abbreviation:  Oral Oncol.     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-01-18     Completed Date:  2012-05-31     Revised Date:  2014-07-31    
Medline Journal Info:
Nlm Unique ID:  9709118     Medline TA:  Oral Oncol     Country:  England    
Other Details:
Languages:  eng     Pagination:  49-55     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Ltd. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Animals
Antigens, CD11b
Bone Marrow Cells / cytology,  metabolism
Bone Neoplasms / metabolism*,  pathology
Bone Resorption / metabolism*,  pathology
Carcinoma, Squamous Cell / metabolism*,  pathology
Female
Hedgehog Proteins / metabolism*
Humans
Mice
Mice, Inbred BALB C
Mice, Nude
Mouth Neoplasms / metabolism*,  pathology
Neoplasms, Experimental
RNA, Small Interfering
Reverse Transcriptase Polymerase Chain Reaction
Stromal Cells / cytology,  metabolism
Tibia / pathology*
Chemical
Reg. No./Substance:
0/Antigens, CD11b; 0/Hedgehog Proteins; 0/RNA, Small Interfering; 0/SHH protein, human

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