Document Detail


Somitic origin of the medial border of the mammalian scapula and its homology to the avian scapula blade.
MedLine Citation:
PMID:  20136669     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The scapula is the main skeletal element of the pectoral girdle allowing muscular fixation of the forelimb to the axial skeleton. The vertebrate limb skeleton has traditionally been considered to develop from the lateral plate mesoderm, whereas the musculature originates from the axial somites. However, in birds, the scapular blade has been shown to develop from the somites. We investigated whether a somitic contribution was also present in the mammalian scapula. Using genetic lineage-tracing techniques, we show that the medial border of the mammalian scapula develops from somitic cells. The medial scapula border serves as the attachment site of girdle muscles (serratus anterior, rhomboidei and levator scapulae). We show that the development of these muscles is independent of the mechanism that controls the formation of all other limb muscles. We suggest that these muscles be specifically referred to as medial girdle muscles. Our results establish the avian scapular blade and medial border of the mammalian scapula as homologous structures as they share the same developmental origin.
Authors:
Petr Valasek; Susanne Theis; Eliska Krejci; Milos Grim; Flavio Maina; Yulia Shwartz; Anthony Otto; Ruijin Huang; Ketan Patel
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-01-28
Journal Detail:
Title:  Journal of anatomy     Volume:  216     ISSN:  1469-7580     ISO Abbreviation:  J. Anat.     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-05-07     Completed Date:  2010-09-16     Revised Date:  2012-09-24    
Medline Journal Info:
Nlm Unique ID:  0137162     Medline TA:  J Anat     Country:  England    
Other Details:
Languages:  eng     Pagination:  482-8     Citation Subset:  IM    
Affiliation:
School of Biological Sciences, University of Reading, Reading, UK. valasekpetr@hotmail.com
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MeSH Terms
Descriptor/Qualifier:
Animals
Biological Evolution
Birds
Cell Differentiation / physiology
Humans
Mice
Models, Biological
Paired Box Transcription Factors / genetics
Scapula / anatomy & histology,  embryology*
Somites / physiology*
Grant Support
ID/Acronym/Agency:
//Wellcome Trust
Chemical
Reg. No./Substance:
0/Paired Box Transcription Factors
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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