Document Detail

Some special skin tumours in the elderly.
MedLine Citation:
PMID:  2186789     Owner:  NLM     Status:  MEDLINE    
A review of uncommon skin tumours, all of which characteristically arise in elderly patients, is presented. Angiosarcoma of the face and scalp is a highly progressive tumour with a poor prognosis, but initially it may be misdiagnosed as a simple bruise or cellulitis. In well-differentiated tumours a characteristic feature is interlacing endothelial cell-lined channels showing considerable nuclear atypia. Merkel cell tumours, which develop as deep-seated nodules in the skin, occur most frequently in photodamaged areas, especially on the head and neck. The prognosis of Merkel cell tumours is generally poor; histological evidence suggests that some of these tumours may be a special type of poorly differentiated squamous cell carcinoma. Atypical fibroxanthoma, which is normally benign, occurs most frequently in elderly, fair-skinned males, especially around the face. It is typically a polypoid lesion with a vascular appearance. Acantholytic squamous cell carcinomas, also known as adenoid squamous cell carcinomas, are most common in fair-skinned men with a history of keratoses. They also occur in the female genital region and the oral mucosa. Histologically, these tumours differ from squamous cell carcinomas because of their tendency to form duct-like areas in tumour lobules.
W E Jones
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The British journal of dermatology     Volume:  122 Suppl 35     ISSN:  0007-0963     ISO Abbreviation:  Br. J. Dermatol.     Publication Date:  1990 Apr 
Date Detail:
Created Date:  1990-06-21     Completed Date:  1990-06-21     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  0004041     Medline TA:  Br J Dermatol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  71-5     Citation Subset:  IM    
Department of Histopathology, University of London, U.K.
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MeSH Terms
Carcinoma, Merkel Cell / pathology
Carcinoma, Squamous Cell / pathology
Fibroma / pathology
Hemangiosarcoma / pathology
Middle Aged
Skin Neoplasms / pathology*,  therapy

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