Document Detail

Some ribosome-inactivating proteins depurinate ribosomal RNA at multiple sites.
MedLine Citation:
PMID:  1520257     Owner:  NLM     Status:  MEDLINE    
Saporin-S6, a ribosome-inactivating protein (RIP) from Saponaria officinalis released more than 1 mol of adenine/mol of ribosomes from house fly (Musca domestica) larvae and from rat liver. The release of adenine from rat liver ribosomes by several RIPs (plant enzymes with RNA N-glycosidase activity) was examined. Saporins, pokeweed antiviral protein from roots of Phytolacca americana (PAP-R), and trichokirin from Trichosanthes kirilowii seeds depurinated rat liver ribosomes at more than one site. Up to 33 mol of adenine were released from 1 mol of ribosomes. This property is not common to all RIPS.
L Barbieri; J M Ferreras; A Barraco; P Ricci; F Stirpe
Related Documents :
10205677 - Cloning and functional expression of raop9l a new member of aquaporin family from rat l...
7663527 - High yield expression of functionally active human liver cyp2d6 in yeast cells.
4062897 - Properties of cadmium-binding proteins in rat testes. characteristics unlike metallothi...
2029527 - Structurally different rat liver medium-chain acyl coa dehydrogenases directed by compl...
1628647 - Distinct forms of human cdc2 identified by novel monoclonal antibodies.
2927447 - Identification, synthesis and immunogenicity of cuticular collagens from the filarial n...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Biochemical journal     Volume:  286 ( Pt 1)     ISSN:  0264-6021     ISO Abbreviation:  Biochem. J.     Publication Date:  1992 Aug 
Date Detail:
Created Date:  1992-10-06     Completed Date:  1992-10-06     Revised Date:  2010-09-07    
Medline Journal Info:
Nlm Unique ID:  2984726R     Medline TA:  Biochem J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1-4     Citation Subset:  IM    
Dipartimento di Patologia Sperimentale, Università di Bologna, Italy.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Antineoplastic Agents, Phytogenic / pharmacology*
Dose-Response Relationship, Drug
Liver / metabolism
N-Glycosyl Hydrolases*
Plant Proteins / isolation & purification,  pharmacology*
RNA, Ribosomal / metabolism*
Ribosome Inactivating Proteins, Type 1
Ribosomes / drug effects,  metabolism*
Reg. No./Substance:
0/Antineoplastic Agents, Phytogenic; 0/Immunotoxins; 0/Plant Proteins; 0/RNA, Ribosomal; 0/Ribosome Inactivating Proteins, Type 1; EC 3.2.2.-/N-Glycosyl Hydrolases; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Duplication of the structural gene for glucosephosphate isomerase and phosphogluconate dehydrogenase...
Next Document:  L-tryptophan uptake by segment-specific membrane vesicles from the proximal tubule of rabbit kidney.