Document Detail


Some ribosome-inactivating proteins depurinate ribosomal RNA at multiple sites.
MedLine Citation:
PMID:  1520257     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Saporin-S6, a ribosome-inactivating protein (RIP) from Saponaria officinalis released more than 1 mol of adenine/mol of ribosomes from house fly (Musca domestica) larvae and from rat liver. The release of adenine from rat liver ribosomes by several RIPs (plant enzymes with RNA N-glycosidase activity) was examined. Saporins, pokeweed antiviral protein from roots of Phytolacca americana (PAP-R), and trichokirin from Trichosanthes kirilowii seeds depurinated rat liver ribosomes at more than one site. Up to 33 mol of adenine were released from 1 mol of ribosomes. This property is not common to all RIPS.
Authors:
L Barbieri; J M Ferreras; A Barraco; P Ricci; F Stirpe
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Biochemical journal     Volume:  286 ( Pt 1)     ISSN:  0264-6021     ISO Abbreviation:  Biochem. J.     Publication Date:  1992 Aug 
Date Detail:
Created Date:  1992-10-06     Completed Date:  1992-10-06     Revised Date:  2010-09-07    
Medline Journal Info:
Nlm Unique ID:  2984726R     Medline TA:  Biochem J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1-4     Citation Subset:  IM    
Affiliation:
Dipartimento di Patologia Sperimentale, Università di Bologna, Italy.
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MeSH Terms
Descriptor/Qualifier:
Animals
Antineoplastic Agents, Phytogenic / pharmacology*
Dose-Response Relationship, Drug
Houseflies
Immunotoxins*
Kinetics
Larva
Liver / metabolism
N-Glycosyl Hydrolases*
Plant Proteins / isolation & purification,  pharmacology*
RNA, Ribosomal / metabolism*
Rats
Ribosome Inactivating Proteins, Type 1
Ribosomes / drug effects,  metabolism*
Chemical
Reg. No./Substance:
0/Antineoplastic Agents, Phytogenic; 0/Immunotoxins; 0/Plant Proteins; 0/RNA, Ribosomal; 0/Ribosome Inactivating Proteins, Type 1; EC 3.2.2.-/N-Glycosyl Hydrolases; EC 3.2.2.22/saporin
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