Document Detail

Some relations between teratogenesis and mutagenesis.
MedLine Citation:
PMID:  1202336     Owner:  NLM     Status:  MEDLINE    
The nonactinic environmental agents that have been found to induce mutations in laboratory mammals are almost without exception of a single chemical class, alkylating chemicals, whereas this class is only one of the numerous sorts of environmental agents that induce congenital structural malformations. Many other types of chemical teratogens as well as nonchemical teratogens exist. This conspicuous difference between the known means of producing these phenomena reflects the fact that the mechanism by which malformations and mutations arise are for the most part distinctly different from each other. Therefore, environmentally induced malformations and mutations cannot be equated with each other and used as mutual indicators in monitoring potential harmful effects of the environment.
H Kalter
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Mutation research     Volume:  33     ISSN:  0027-5107     ISO Abbreviation:  Mutat. Res.     Publication Date:  1975 Nov 
Date Detail:
Created Date:  1976-03-01     Completed Date:  1976-03-01     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0400763     Medline TA:  Mutat Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  29-36     Citation Subset:  IM    
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MeSH Terms
Abnormalities, Drug-Induced*
Chromosome Aberrations / genetics
Chromosome Disorders
Dose-Response Relationship, Drug
Environmental Exposure
Reg. No./Substance:
0/Mutagens; 0/Teratogens

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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