Document Detail

Some properties of the colony forming cell in adult acute leukaemia.
MedLine Citation:
PMID:  288388     Owner:  NLM     Status:  MEDLINE    
Variations in the concentration and physical characteristics of the bone marrow derived colony forming cell(CFC) have been studied in patients with acute leukaemia. Two-hundred-and-fifteen marrow samples from 83 patients provide the basis for this analysis. CFC concentration confirmed the clinical remission/relapse status and yielded some guidelines to prognosis in individual patients while the proportions of CFC in DNA synthesis also proved to be a most reliable indicator of disease status. In remission, CFC concentrations return to normal values whilst on presentation and in the relapse phase of acute leukaemia CFC numbers are reduced. Biophysical profiles of CFC established using albumin density gradient and velocity sedimentation studies also indicated the state of the leukaemic process in individual patients. By applying physical laws to the data obtained from such profiles, the mean volume, diameter, density and mass of CFC were calculated. CFC from leukaemic patients in relapse were up to twice the volume and mass although slightly less dense than CFC from normal patients. The reasons for these changes are explained and discussed.
K A Rickard; R D Brown; E Yuen; D Joshua; T Wilkinson; H Kronenberg
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Australian and New Zealand journal of medicine     Volume:  9     ISSN:  0004-8291     ISO Abbreviation:  Aust N Z J Med     Publication Date:  1979 Jun 
Date Detail:
Created Date:  1979-09-27     Completed Date:  1979-09-27     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  1264322     Medline TA:  Aust N Z J Med     Country:  AUSTRALIA    
Other Details:
Languages:  eng     Pagination:  233-40     Citation Subset:  IM    
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MeSH Terms
Acute Disease
Bone Marrow / pathology*
Cell Count
Colony-Forming Units Assay*
Leukemia / mortality,  pathology*,  therapy
Leukemia, Myeloid, Acute / pathology
Remission, Spontaneous

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