| Some principles of regeneration in mammalian systems. | |
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MedLine Citation:
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PMID: 16308859 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This article presents some general principles underlying regenerative phenomena in vertebrates, starting with the epimorphic regeneration of the amphibian limb and continuing with tissue and organ regeneration in mammals. Epimorphic regeneration following limb amputation involves wound healing, followed shortly by a phase of dedifferentiation that leads to the formation of a regeneration blastema. Up to the point of blastema formation, dedifferentiation is guided by unique regenerative pathways, but the overall developmental controls underlying limb formation from the blastema generally recapitulate those of embryonic limb development. Damaged mammalian tissues do not form a blastema. At the cellular level, differentiation follows a pattern close to that seen in the embryo, but at the level of the tissue and organ, regeneration is strongly influenced by conditions inherent in the local environment. In some mammalian systems, such as the liver, parenchymal cells contribute progeny to the regenerate. In others, e.g., skeletal muscle and bone, tissue-specific progenitor cells constitute the main source of regenerating cells. The substrate on which regeneration occurs plays a very important role in determining the course of regeneration. Epimorphic regeneration usually produces an exact replica of the structure that was lost, but in mammalian tissue regeneration the form of the regenerate is largely determined by the mechanical environment acting on the regenerating tissue, and it is normally an imperfect replica of the original. In organ hypertophy, such as that occurring after hepatic resection, the remaining liver mass enlarges, but there is no attempt to restore the original form. |
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Authors:
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Bruce M Carlson |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Anatomical record. Part B, New anatomist Volume: 287 ISSN: 1552-4906 ISO Abbreviation: - Publication Date: 2005 Nov |
Date Detail:
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Created Date: 2005-12-05 Completed Date: 2006-03-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101234289 Medline TA: Anat Rec B New Anat Country: United States |
Other Details:
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Languages: eng Pagination: 4-13 Citation Subset: IM |
Copyright Information:
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(c) 2005 Wiley-Liss, Inc. |
Affiliation:
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Institute of Gerontology at the University of Michigan, Ann Arbor 48109, USA. brcarl@umich.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Extremities / physiology Humans Mammals / physiology* Regeneration / physiology* Urodela / physiology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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