| Some principles of the immunology of trypanosomiasis. | |
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MedLine Citation:
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PMID: 4866448 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Although immunological methods have not been used on a wide scale for the study of trypanosomiasis in Africa, there is hope that immunological research will lead to improved methods of diagnosis, methods for the classification of trypanosome strains, better understanding of the epidemiology, epizootiology and pathology of trypanosomiasis, and ultimately the development of methods of immunization against the disease.This paper reviews some of the problems that hinder progress in each of these areas. Such problems include inadequacies in existing methods of obtaining antigens of Trypanosoma vivax, T. congolense, and T. gambiense; the general lack of fundamental information on the nature and properties of trypanosome antigens; and the variability of certain trypanosome antigens in infected animals. Recent progress towards the solution of these problems is summarized, and aspects of the immunology of trypanosomiasis that require further study are discussed. These include the diagnostic value of determinations of IgM globulin levels; the properties of T. vivax and T. congolense antigens; the natural immunity of game animals and certain varieties of cattle to trypanosomiasis; and the possibility of immunizing livestock by exposing drug-treated animals to a continuous low-grade trypanosome challenge. |
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Authors:
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A R Gray |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Bulletin of the World Health Organization Volume: 37 ISSN: 0042-9686 ISO Abbreviation: Bull. World Health Organ. Publication Date: 1967 |
Date Detail:
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Created Date: 1968-04-10 Completed Date: 1968-04-10 Revised Date: 2010-10-26 |
Medline Journal Info:
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Nlm Unique ID: 7507052 Medline TA: Bull World Health Organ Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 177-93 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Africa Animals Antigens Cattle Complement Fixation Tests Humans Immunization Mice Mutation Precipitin Tests Rats Trypanosoma / classification Trypanosomiasis / diagnosis, immunology*, veterinary Trypanosomiasis, Bovine |
| Chemical | |
Reg. No./Substance:
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0/Antigens |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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