Document Detail

Some patients with NHL possessed immunoreactivity to gliadin and to cow's milk proteins.
MedLine Citation:
PMID:  19609644     Owner:  NLM     Status:  MEDLINE    
Non-Hodgkin lymphoma (NHL) represents heterogeneous group of diseases either B, or T cell origin. In order to assess whether food antigens contribute to the imbalance of immune response, the aim of this work was screening the sera of patients with (mostly) B cell NHL, and of people with non-malignant health disorders (NMD), as well as of healthy people for their immunoreactivity to food constituent gliadin, and to cow's milk proteins. Data obtained by ELISA tests show the existence of the enhanced immunoreactivity to food antigens in some NHL patients, as well as in some people with NMD. The high degree of coincidence in the presence of enhanced levels of immune complexes in circulation (CIC) and of immunoreactivity with gliadin in immunofixation (after the serum protein electrophoresis in agarose gel in veronal buffer, at pH 8.6) especially in NHL patients points that some antigliadin immunoreactivity unrevealed in ELISA tests could be hidden in CIC. This, only in the presence of malignant genotype, as well as the enhanced levels of CIC in some of NHL patients could both, at least partially contribute to the persistent non-specific support of disease. They call for the new research of the clinical importance of both, the elevated humoral immunity to food antigens (gluten, cow's milk proteins) for the course of this very severe hematological disease.
Zorica D Juranić; Irina Besu; Svetislav Jelić; Aleksandra Konić-Ristić; Suzana Matković; Ljiljana Janković; Dusica Gavrilović; Branka Radojcić; Ivana Minić
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-07-17
Journal Detail:
Title:  International journal of hematology     Volume:  90     ISSN:  1865-3774     ISO Abbreviation:  Int. J. Hematol.     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2009-08-24     Completed Date:  2009-11-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9111627     Medline TA:  Int J Hematol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  212-6     Citation Subset:  IM    
Institute of Oncology and Radiology of Serbia, Pasterova 14, Belgrade, Serbia.
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MeSH Terms
Aged, 80 and over
Antigen-Antibody Complex / blood
Food Hypersensitivity / epidemiology,  immunology*
Gliadin / immunology*
Immunoglobulin A / blood
Immunoglobulin G / blood
Lymphoma, Non-Hodgkin / epidemiology,  immunology*
Middle Aged
Milk Proteins / immunology*
Seroepidemiologic Studies
Young Adult
Reg. No./Substance:
0/Antigen-Antibody Complex; 0/Immunoglobulin A; 0/Immunoglobulin G; 0/Milk Proteins; 9007-90-3/Gliadin

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