Document Detail


Some oncogene and tumour suppressor gene protein products expression in B-cell chronic lymphocytic leukaemia.
MedLine Citation:
PMID:  11086711     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The expression of Bcl-2, P53 proteins and known markers of proliferation, namely proliferating cell nuclear antigen (PCNA) and Ki67, in 29 patients with B-cell chronic lymphocytic leukaemia (B-CLL) was investigated. All leukaemic patients were classified, and immunophenotyped by the two-colour immunofluorescence method with the use of fluorocytometry. B-CLL was heterogeneous in the range of biological parameters of tumour cells. B-CLL patients manifested 34% positive Ki67 and 61% PCNA expression, whereas Bcl-2 and P53 positivity was 81% and 42%, respectively. The level of intracellular expression of Bcl-2 and P53 proteins did not depend on the stage of disease estimated by routine methods. Ki67 and PCNA expression was significantly higher in B-CLL patients with more advanced stages of the disease. A statistically significant correlation was established between their mutual expression.
Authors:
H Niewiadomska; M Mirowski; D Kulczycka; M Najder; E Balcerczak; J Z Błoński
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cytobios     Volume:  103     ISSN:  0011-4529     ISO Abbreviation:  Cytobios     Publication Date:  2000  
Date Detail:
Created Date:  2001-02-09     Completed Date:  2001-03-01     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0207227     Medline TA:  Cytobios     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  159-68     Citation Subset:  IM    
Affiliation:
Department of Oncology, Medical University of Lódź, Poland.
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MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Cell Count
Female
Flow Cytometry
Genes, Tumor Suppressor / physiology*
Humans
Ki-67 Antigen / metabolism*
Leukemia, Lymphocytic, Chronic, B-Cell / metabolism*
Male
Middle Aged
Oncogenes / physiology*
Proliferating Cell Nuclear Antigen / metabolism*
Proto-Oncogene Proteins c-bcl-2 / metabolism*
Tumor Suppressor Protein p53 / metabolism*
Chemical
Reg. No./Substance:
0/Ki-67 Antigen; 0/Proliferating Cell Nuclear Antigen; 0/Proto-Oncogene Proteins c-bcl-2; 0/Tumor Suppressor Protein p53

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